Probiotics partly reverse increased bacterial translocation after simultaneous liver resection and colonic anastomosis in rats

Seehofer, Daniel; Rayes, Nada; Schiller, R.; Stockmann, Martin; Müller, A.R; Schirmeier, Anja; Schaeper, Frank; Tullius, Stefan G.; Bengmark, S; Neuhaus, P.

doi:10.1016/j.jss.2003.11.021

Cited by 47 publications

(23 citation statements)

References 36 publications

(43 reference statements)

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“…[9][10][11] Probiotics are bacteria which can provide beneficial effect through maintaining the balance of resident bacteria in the bowel such as bifidus bacterium and lactobacterium etc. 12,13 Generally, probiotics increase the intestinal motility, and stabilize the intestinal barrier for bacterial location. 14,15 Furthermore, probiotics, which are living bacteria, can protect EGUCHI et al 4 the innate immune system with cytokine modulation.…”

mentioning

confidence: 99%

Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation: a prospective randomized study

Eguchi

Takatsuki

Hidaka

et al. 2011

The American Journal of Surgery

107

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confidence: 99%

Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation: a prospective randomized study

Eguchi

Takatsuki

Hidaka

et al. 2011

The American Journal of Surgery

107

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“…It has been shown that probiotics are able to decrease and prevent, to a certain degree, bacterial translocation [14,15]. Probiotics are food supplements containing live bacteria that, theoretically, have beneficial effects in the host, although a scientifically sound corroboration of these effects is not yet available for most, if not for all conditions.…”

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confidence: 99%

Does the use of probiotics/synbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials

Pitsouni

Alexiou

Saridakis

et al. 2009

Eur J Clin Pharmacol

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Background Advances in surgery have considerably lowered postoperative morbidity. However, infection remains a considerable morbidity factor. The aim of this review is to identify the potential benefit(s) of the perioperative administration of probiotics/synbiotics to patients undergoing abdominal surgery. Methods We searched PubMed, Scopus, Web of Science, and Cochrane library to identify randomized controlled trials (RCTs) that studied the perioperative administration of probiotics/synbiotics to patients undergoing abdominal surgery. Results Nine RCTs studying 733 patients were included in our review. The incidence of postoperative pneumonia, cholangitis, and any infections as well as the duration of postoperative hospital stay and length of antibiotic therapy were lower among patients receiving probiotics than in the control group [six RCTs, 355 patients, odds ratio (OR) 0.24, 95% confidence interval (CI) 0.09-0.68; three RCTs, 209 patients, OR0.18, 95% CI0.05-0.57; seven RCTs, 514 patients, OR 0.26, 95% CI 0.12-0.55; five RCTs, 313 patients, OR −2.70, 95% CI−5.15 to −0.25; four RCTs, 250 patients, OR −4.01, 95% CI−5.11 to −2.92, respectively], while the incidence of postoperative wound infection, urinary tract infection, intra-abdominal abscess, and mortality was not different between patients of the compared groups (six RCTs, 355 patients, OR0.52, 95% CI0.23-1.18; five RCTs, 313 patients, OR0.44, 95% CI0. four RCTs, 226 patients, OR0.44, nine RCTs, 685 patients, OR0.98, respectively). Conclusion The use of probiotics/synbiotics may reduce postoperative infections after abdominal surgery. This is a promising infection-preventive measure that may decrease morbidity, length of antibiotic therapy, duration of hospital stay, and pressure for emergence of antimicrobial resistance. However, the results of this meta-analysis should be interpreted with caution due to the significant heterogeneity of the studies included.

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“…In addition, TLR signaling is important in the anti-inflammatory effects of probiotics [35] . These data show the critical role of bacteria in shaping the immune response and underscore the current interest in probiotic effects on permeability [36][37][38] that may act to limit polarization to Th1 or Th2 responses and, thereby, maintain intestinal barrier function.…”

Section: Innate and Adaptive Immunity And Their Interactionsmentioning

confidence: 62%

Understanding the Dialogue: the Microbial–Host Interaction

Fasano¹

2009

Ann Nestlé [Engl]

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The mammalian gastrointestinal tract is much more complex than previously appreciated. A single layer of epithelial cells covers the entire gastrointestinal tract, so providing the largest interface with the environment. The gut epithelium is a sensor of the luminal environment, not only controlling digestive, absorptive, and secretory functions, but also relaying information to the mucosal immune, vascular and nervous systems. These functions involve a complex array of pattern recognition receptors (PRRs) and cell types that elaborate growth factors, cytokines, and extracellular matrix proteins. Moreover, enteric microbes may hijack PRR-activated pathways as part of their pathogenic arsenal through ‘host mimicry’. Understanding the cross-talk between enteric microbiota and the host under both physiological and pathological circumstances may provide key information on the pathogenesis of local as well as systemic diseases. This knowledge may potentially lead to the identification of novel therapeutic strategies for the treatment of these disorders.

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Probiotics partly reverse increased bacterial translocation after simultaneous liver resection and colonic anastomosis in rats

Cited by 47 publications

References 36 publications

Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation: a prospective randomized study

Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation: a prospective randomized study

Does the use of probiotics/synbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials

Understanding the Dialogue: the Microbial–Host Interaction

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