Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence

Araújo, Maísa Miranda; Botelho, Patrícia Borges

doi:10.3389/fnut.2022.935830

Cited by 23 publications

(11 citation statements)

References 126 publications

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“…Likewise, the hydrolyzed chia protein might have similar effects, as demonstrated in the current study. Probiotic bacteria play a role in the regulation of the immune response by stimulating immune cells through the modulation of intestinal microbiota and downregulating inflammation [21,22]. Some of these bacteria might be useful in mitigating intestinal inflammation; specifically, Lactobacillus and Bifidobacteria demonstrate antimicrobial effects by affecting both local and systemic immune responses [20,45].…”

Section: Discussionmentioning

confidence: 99%

“…Probiotics are live microorganisms that, when administered in adequate amounts, confer benefits to the health of the host. Probiotic use supports a healthy digestive tract and a healthy immune system, so the overall benefit of probiotics on the gut microbiota derives from creating a favorable gut environment [20][21][22]. Probiotic food products represent a market trend, being associated with the increasing consumer awareness regarding the link between diet and well-being, and especially gut health.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Intra-Amniotic Administration of the Hydrolyzed Protein of Chia (Salvia hispanica L.) and Lacticaseibacillus paracasei on Intestinal Functionality, Morphology, and Bacterial Populations, In Vivo (Gallus gallus)

et al. 2023

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As a protein source, chia contains high concentrations of bioactive peptides. Probiotics support a healthy digestive tract and immune system. Our study evaluated the effects of the intra-amniotic administration of the hydrolyzed chia protein and the probiotic Lacticaseibacillus paracasei on intestinal bacterial populations, the intestinal barrier, the inflammatory response, and brush border membrane functionality in ovo (Gallus gallus). Fertile broiler (Gallus gallus) eggs (n = 9/group) were divided into 5 groups: (NI) non-injected; (H2O) 18 MΩ H2O; (CP) 10 mg/mL hydrolyzed chia protein; (CPP) 10 mg/mL hydrolyzed chia protein + 106 colony-forming unit (CFU) L. paracasei; (P) 106 CFU L. paracasei. The intra-amniotic administration was performed on day 17 of incubation. At hatching (day 21), the animals were euthanized, and the duodenum and cecum content were collected. The probiotic downregulated the gene expression of NF-κβ, increased Lactobacillus and E. coli, and reduced Clostridium populations. The hydrolyzed chia protein downregulated the gene expression of TNF-α, increased OCLN, MUC2, and aminopeptidase, reduced Bifidobacterium, and increased Lactobacillus. The three experimental groups improved in terms of intestinal morphology. The current results suggest that the intra-amniotic administration of the hydrolyzed chia protein or a probiotic promoted positive changes in terms of the intestinal inflammation, barrier, and morphology, improving intestinal health.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Intra-Amniotic Administration of the Hydrolyzed Protein of Chia (Salvia hispanica L.) and Lacticaseibacillus paracasei on Intestinal Functionality, Morphology, and Bacterial Populations, In Vivo (Gallus gallus)

et al. 2023

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“…Synbiotics combined probiotics with prebiotics, improving the survival of formula probiotics as well as the reproduction of intestinal probiotics 50. In our included studies, the most popular probiotics ingredients were Bifidobacterium and Lactobacillus , while the most popular prebiotics ingredients were inulin, fructooligosaccharide and psyllium 51. The change of gut microbiota was researched through the comparison between pretreatment and post-treatment stage in the intervention group, or between the intervention group and the control group in post-treatment stage.…”

Section: Discussionmentioning

confidence: 99%

“… 50 In our included studies, the most popular probiotics ingredients were Bifidobacterium and Lactobacillus , while the most popular prebiotics ingredients were inulin, fructooligosaccharide and psyllium. 51 The change of gut microbiota was researched through the comparison between pretreatment and post-treatment stage in the intervention group, or between the intervention group and the control group in post-treatment stage. There is still a lack of appropriate methodology to measure the synergistic effects of probiotics combined with prebiotics on gut microbiota, compared with probiotics alone.…”

Section: Discussionmentioning

confidence: 99%

Efficacy in bowel movement and change of gut microbiota on adult functional constipation patients treated with probiotics-containing products: a systematic review and meta-analysis

Ding,

Hu,

Ding

et al. 2024

BMJ Open

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ObjectivesThis study aimed to pool the efficacy in bowel movement and explore the change of gut microbiota on adult functional constipated patients after probiotics-containing products treatment.DesignSystematic review and meta-analysis.Data sourcesPubMed, Cochrane Library for published studies and ClinicalTrials.gov for ‘grey’ researches were independently investigated for randomised controlled trials up to November 2022.Eligibility criteria, data extraction and synthesisThe intervention was probiotics-containing product, either probiotics or synbiotics, while the control was placebo. The risk of bias was conducted. The efficacy in bowel movement was indicated by stool frequency, stool consistency and Patient Assessment of Constipation Symptom (PAC-SYM), while the change of gut microbiota was reviewed through α diversity, β diversity, change/difference in relative abundance and so on. The subgroup analysis, sensitivity analysis and random-effect meta-regression were conducted to explore the heterogeneity. The Grading of Recommendations Assessment Development and Evaluation was conducted to grade the quality of evidence.Results17 studies, comprising 1256 participants, were included with perfect agreements between two researchers (kappa statistic=0.797). Compared with placebo, probiotics-containing products significantly increased the stool frequency (weighted mean difference, WMD 0.93, 95% CI 0.47 to 1.40, p=0.000, I²=84.5%, ‘low’), improved the stool consistency (WMD 0.38, 95% CI 0.05 to 0.70, p=0.023, I²=81.6%, ‘very low’) and reduced the PAC-SYM (WMD −0.28, 95% CI: −0.45 to −0.11, p=0.001, I²=55.7%, ‘very low’). In subgroup analysis, synbiotics was superior to probiotics to increase stool frequency. Probiotics-containing products might not affect α or β diversity, but would increase the relative abundance of specific strain.ConclusionsProbiotics-containing products, significantly increased stool frequency, improved stool consistency, and alleviated functional constipation symptoms. They increased the relative abundance of specific strain. More high-quality head-to-head randomised controlled trials are needed.

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“…In medical practice, probiotics are often used to treat functional diseases of the gastrointestinal tract, beneficially altering the gut microbiota and relieving abdominal symptoms, including constipation [ 51 , 52 , 53 ]. Probiotics may improve intestinal transit time, stool consistency, and frequency [ 54 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Tryptophan Metabolism in Postmenopausal Women with Functional Constipation

Blonska,

Chojnacki,

Macieja

et al. 2023

IJMS

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Constipation belongs to conditions commonly reported by postmenopausal women, but the mechanism behind this association is not fully known. The aim of the present study was to determine the relationship between some metabolites of tryptophan (TRP) and the occurrence and severity of abdominal symptoms (Rome IV) in postmenopausal women with functional constipation (FC, n = 40) as compared with age-adjusted postmenopausal women without FC. All women controlled their TRP intake in their daily diet. Urinary levels of TRP and its metabolites, 5-hydroxyindoleacetic acid (5-HIAA), kynurenine (KYN), and 3-indoxyl sulfate (indican, 3-IS), were determined by liquid chromatography/tandem mass spectrometry. Dysbiosis was assessed by a hydrogen–methane breath test. Women with FC consumed less TRP and had a lower urinary level of 5-HIAA, but higher levels of KYN and 3-IS compared with controls. The severity of symptoms showed a negative correlation with the 5-HIAA level, and a positive correlation with the 3-IS level. In conclusion, changes in TRP metabolism may contribute to FC in postmenopausal women, and dysbiosis may underlie this contribution.

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Probiotics, prebiotics, and synbiotics in chronic constipation: Outstanding aspects to be considered for the current evidence

Cited by 23 publications

References 126 publications

Effects of Intra-Amniotic Administration of the Hydrolyzed Protein of Chia (Salvia hispanica L.) and Lacticaseibacillus paracasei on Intestinal Functionality, Morphology, and Bacterial Populations, In Vivo (Gallus gallus)

Effects of Intra-Amniotic Administration of the Hydrolyzed Protein of Chia (Salvia hispanica L.) and Lacticaseibacillus paracasei on Intestinal Functionality, Morphology, and Bacterial Populations, In Vivo (Gallus gallus)

Efficacy in bowel movement and change of gut microbiota on adult functional constipation patients treated with probiotics-containing products: a systematic review and meta-analysis

Tryptophan Metabolism in Postmenopausal Women with Functional Constipation

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