Probiotics-rich emulsion improves insulin signalling in Palmitate/Oleate-challenged human hepatocarcinoma cells through the modulation of Fetuin-A/TLR4-JNK-NF-κB pathway

Mularczyk, Malwina; Bourebaba, Yasmina; Kowalczuk, Anna; Marycz, Krzyzstof; Bourebaba, Lynda

doi:10.1016/j.biopha.2021.111560

Cited by 17 publications

(13 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Probiotics must be resistant to food operating, storage, and intestinal conditions to reach their intended location and show health effects with a minimum amount 10 6 -10 7 cfu/g Mularczyk et al, 2021;Rezazadeh-Bari et al, 2019;Vallejo-Castillo et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of Lactobacillus acidophilus LA‐5 and Bifidobacterium animalis BB‐12 in pectin and sodium alginate: A comparative study on viability, stability, and structure

Moghanjougi

Bari

Khaledabad

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Microencapsulation of Lactobacillus acidophilus LA‐5 and Bifidobacterium animalis BB‐12 in pectin and sodium alginate: A comparative study on viability, stability, and structure

Moghanjougi

Bari

Khaledabad

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…L. reuteri ATCC treated mice gained significantly less body weight than the control mice [ 50 ] and another strain of L. reuteri increased the expression of Cpt1a (gene involved in fatty acid oxidation pathway) in obese mice, although the lipogenic genes in the liver of mice were not altered by the probiotics [ 50 ]. L. rhamnosus NCIMB 8010 and Pediococcus acidilactici NCIMB 8018 improved the viability of human hepatocellular carcinoma cell line HepG2, protected against apoptosis under normal and insulin resistance conditions and attenuated oxidative stress by improving mitochondrial metabolism and dynamics [ 51 ]. Bifidobacterium supplementation ameliorated visceral fat accumulation and insulin sensitivity of the metabolic syndrome in rats under high fat diet [ 52 ].…”

Section: Administration Of Probiotic Supplementsmentioning

confidence: 99%

Microbiota Modulation in Patients with Metabolic Syndrome

2022

View full text Add to dashboard Cite

Metabolic syndrome (MS) comprises a vast range of metabolic dysfunctions, which can be associated to cardiovascular disease risk factors. MS is reaching pandemic levels worldwide and it currently affects around 25% in the adult population of developed countries. The definition states for the diagnosis of MS may be clear, but it is also relevant to interpret the patient data and realize whether similar criteria were used by different clinicians. The different criteria explain, at least in part, the controversies on the theme. Several studies are presently focusing on the microbiota changes according to the components of MS. It is widely accepted that the gut microbiota is a regulator of metabolic homeostasis, being the gut microbiome in MS described as dysbiotic and certain taxonomic groups associated to metabolic changes. Probiotics, and more recently synbiotics, arise as promising therapeutic alternatives that can mitigate some metabolic disturbances, namely by correcting the microbiome and bringing homeostasis to the gut. The most recent studies were revised and the promising results and perspectives revealed in this review.

show abstract

“…Meanwhile, earlier work also found that AHSG acts as an endogenous ligand for TLR4, which not only promotes lipid-induced IR, but also mediates the activation of TLR4 and NF- κ B pathways leading to an inflammatory cascade [ 61 ]. Reduction of ASHG/TLR4/JNK/NF- κ B pathway activation exerts a protective effect against inflammation and obesity as well as liver-related insulin resistance [ 62 ]. Some studies have shown that NF- κ B can regulate ASHG promoter activity [ 63 ].…”

Section: Hepatokines and Nf- κ B Activationmentioning

confidence: 99%

Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease

Yang

Tan

et al. 2022

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

The pathogenesis of NAFLD is complex and diverse, involving multiple signaling pathways and cytokines from various organs. Hepatokines, stellakines, adipokines, and myokines secreted by hepatocytes, hepatic stellate cells, adipose tissue, and myocytes play an important role in the occurrence and development of nonalcoholic fatty liver disease (NAFLD). The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) contributes to the progression of NAFLD by mediating liver inflammation, immune response, hepatocyte death, and later compensatory proliferation. In this review, we first discuss the crosstalk and interaction between hepatokines, stellakines, adipokines, and myokines and NF-κB in NAFLD. The characterization of the crosstalk of NF-κB with these factors will provide a better understanding of the molecular mechanisms involved in the progression of NAFLD. In addition, we examine new expert management opinions for NAFLD and explore the therapeutic potential of silymarin in NAFLD/NASH.

show abstract

Probiotics-rich emulsion improves insulin signalling in Palmitate/Oleate-challenged human hepatocarcinoma cells through the modulation of Fetuin-A/TLR4-JNK-NF-κB pathway

Cited by 17 publications

References 76 publications

Microencapsulation of Lactobacillus acidophilus LA‐5 and Bifidobacterium animalis BB‐12 in pectin and sodium alginate: A comparative study on viability, stability, and structure

Microencapsulation of Lactobacillus acidophilus LA‐5 and Bifidobacterium animalis BB‐12 in pectin and sodium alginate: A comparative study on viability, stability, and structure

Microbiota Modulation in Patients with Metabolic Syndrome

Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease

Contact Info

Product

Resources

About