Probiotics supplementation and brain-derived neurotrophic factor (BDNF): a systematic review and meta-analysis of randomized controlled trials

Dehghani, Fereshteh; Abdollahi, Shima; Shidfar, Farzad; Clark, Cain C. T.; Soltani, Sepideh

doi:10.1080/1028415x.2022.2110664

Cited by 26 publications

(15 citation statements)

References 93 publications

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“…Recent systematic reviews and meta-analyses have concluded that Lactobacillus and Bifidobacterium probiotics have the most significant effect on the augmentation of BDNF levels in patients with depression. L. helveticus R0052 and B. longum R0175 are the most commonly studied probiotics associated with such an effect on the BDNF levels in depression [ 155 , 156 , 157 ].…”

Section: A Conceptual Framework Of Probiotics Aligned To Precision Ps...mentioning

confidence: 99%

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

Johnson

Letchumanan

Thum³

et al. 2023

Nutrients

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Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents a key domain of healthcare, which currently has limited, adverse-effect prone treatment options, and probiotics may hold the potential to be a novel, customizable treatment for depression. Clinical depression is a common, potentially debilitating condition that may be amenable to a precision psychiatry-based approach utilizing probiotics. Although our understanding has not yet reached a sufficient level, this could be a therapeutic approach that can be tailored for specific individuals with their own unique set of characteristics and health issues. Scientifically, the use of probiotics as a treatment for depression has a valid basis rooted in the microbiota-gut-brain axis (MGBA) mechanisms, which play a role in the pathophysiology of depression. In theory, probiotics appear to be ideal as adjunct therapeutics for major depressive disorder (MDD) and as stand-alone therapeutics for mild MDD and may potentially revolutionize the treatment of depressive disorders. Although there is a wide range of probiotics and an almost limitless range of therapeutic combinations, this review aims to narrow the focus to the most widely commercialized and studied strains, namely Lactobacillus and Bifidobacterium, and to bring together the arguments for their usage in patients with major depressive disorder (MDD). Clinicians, scientists, and industrialists are critical stakeholders in exploring this groundbreaking concept.

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Section: A Conceptual Framework Of Probiotics Aligned To Precision Ps...mentioning

confidence: 99%

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

Johnson

Letchumanan

Thum³

et al. 2023

Nutrients

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“…The promising role of probiotics in depression via in vivo and in vitro studies have laid a strong foundation for clinical application. Several recent randomized controlled trials (RCTs) have demonstrated that probiotics can alleviate depressive symptoms in participants both with and without a clinical diagnosis of depression effectively ( Goh et al., 2019 ; Amirani et al., 2020 ; Chao et al., 2020 ; Dehghani et al., 2022 ). Probiotics exhibit antidepressant properties in the absence of other therapeutic options ( Nikolova et al., 2021 ).…”

Section: Therapeutic Potential Of Probiotics On Depressionmentioning

confidence: 99%

Probiotics for the treatment of depression and its comorbidities: A systemic review

Gao

Zhao

Cheng

et al. 2023

Front. Cell. Infect. Microbiol.

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Depression is one of the most common psychiatric conditions, characterized by significant and persistent depressed mood and diminished interest, and often coexists with various comorbidities. The underlying mechanism of depression remain elusive, evidenced by the lack of an appreciate therapy. Recent abundant clinical trials and animal studies support the new notion that the gut microbiota has emerged as a novel actor in the pathophysiology of depression, which partakes in bidirectional communication between the gut and the brain through the neuroendocrine, nervous, and immune signaling pathways, collectively known as the microbiota-gut-brain (MGB) axis. Alterations in the gut microbiota can trigger the changes in neurotransmitters, neuroinflammation, and behaviors. With the transition of human microbiome research from studying associations to investigating mechanistic causality, the MGB axis has emerged as a novel therapeutic target in depression and its comorbidities. These novel insights have fueled idea that targeting on the gut microbiota may open new windows for efficient treatment of depression and its comorbidities. Probiotics, live beneficial microorganisms, can be used to modulate gut dysbiosis into a new eubiosis and modify the occurrence and development of depression and its comorbidities. In present review, we summarize recent findings regarding the MGB axis in depression and discuss the potential therapeutic effects of probiotics on depression and its comorbidities.

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“…While these reports demonstrated that probiotics affect BDNF levels in the hippocampus, a meta-analysis of 11 trials (n = 648 participants) indicated that more large-scale, high-quality, randomised controlled trials are needed to make reliable conclusions in their relationship [ 77 ].…”

Section: Gut Microbiota and Bdnf Expression In The Brainmentioning

confidence: 99%

Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve

Amagase

Kambayashi

Sugiyama

et al. 2023

IJMS

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The brain-derived neurotrophic factor (BDNF) is an extensively studied neurotrophin es sential for both developing the brain and maintaining adult brain function. In the adult hippocampus, BDNF is critical for maintaining adult neurogenesis. Adult hippocampal neurogenesis is involved not only in memory formation and learning ability, but also mood regulation and stress responses. Accordingly, decreased levels of BDNF, accompanied by low levels of adult neurogenesis, occurs in brains of older adults with impaired cognitive function and in those of patients with major depression disorder. Therefore, elucidating the mechanisms that maintain hippocampal BDNF levels is biologically and clinically important. It has been revealed that signalling from peripheral tissues contribute to the regulation of BDNF expression in the brain across the blood–brain barrier. Moreover, recent studies indicated evidence that neuronal pathways can also be a mechanism by which peripheral tissues signal to the brain for the regulation of BDNF expression. In this review, we give an overview of the current status in the regulation of central BDNF expression by peripheral signalling, with a special interest in the regulation of hippocampal BDNF levels by signals via the vagus nerve. Finally, we discuss the relationship between signalling from peripheral tissues and age-associated control of central BDNF expression.

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Probiotics supplementation and brain-derived neurotrophic factor (BDNF): a systematic review and meta-analysis of randomized controlled trials

Cited by 26 publications

References 93 publications

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

Probiotics for the treatment of depression and its comorbidities: A systemic review

Peripheral Regulation of Central Brain-Derived Neurotrophic Factor Expression through the Vagus Nerve

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