Probiotics supplementation increases intestinal blood flow velocity in extremely low birth weight preterm infants

Havranek, Thomas; Al-Hosni, Mohamad; Armbrecht, Eric S.

doi:10.1038/jp.2012.37

Cited by 20 publications

(17 citation statements)

References 20 publications

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“…Butyrate plays an important role in the regulation of transepithelial fluid transport, maintaining epithelial integrity, ameliorating mucosal oxidative status, and inflammation and modulating gut motility and visceral sensitivity (77,78). Evidence from a small, randomized, double-blind, placebo-controlled trial indicated that probiotic supplementation significantly improved the postprandial superior mesenteric artery flow (P = 0.035) (57), which is another possible pathway by which probiotics may improve feed tolerance because a rise in the postprandial mesenteric flow is essential for food digestion (57).…”

Section: Discussionmentioning

confidence: 93%

Benefits of probiotics on enteral nutrition in preterm neonates: a systematic review

Athalye-Jape

Deshpande

Rao

et al. 2014

The American Journal of Clinical Nutrition

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Section: Discussionmentioning

confidence: 93%

Benefits of probiotics on enteral nutrition in preterm neonates: a systematic review

Athalye-Jape

Deshpande

Rao

et al. 2014

The American Journal of Clinical Nutrition

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“…As shown in Figure 1, 35 studies met the inclusion criteria [21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55]. Fourteen additional papers were identified from the reference lists of included studies or by “snowballing” techniques [52,56,57,58,59,60,61,62,63,64,65,66,67,68].…”

Section: Resultsmentioning

confidence: 99%

“…Twenty-four studies were excluded after examining the full-texts [28,29,31,32,33,35,42,43,44,45,46,47,51,53,54,55,57,58,59,62,63,65,69]. Twenty-five studies were then suitable for inclusion in the systematic review (Table 1) [21,22,23,24,25,26,27,30,34,36,37,38,39,40,41,48,49,50,56,60,61,64,66,68,70].…”

Section: Resultsmentioning

confidence: 99%

Probiotics and Time to Achieve Full Enteral Feeding in Human Milk-Fed and Formula-Fed Preterm Infants: Systematic Review and Meta-Analysis

et al. 2016

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Probiotics have been linked to a reduction in the incidence of necrotizing enterocolitis and late-onset sepsis in preterm infants. Recently, probiotics have also proved to reduce time to achieve full enteral feeding (FEF). However, the relationship between FEF achievement and type of feeding in infants treated with probiotics has not been explored yet. The aim of this systematic review and meta-analysis was to evaluate the effect of probiotics in reducing time to achieve FEF in preterm infants, according to type of feeding (exclusive human milk (HM) vs. formula). Randomized-controlled trials involving preterm infants receiving probiotics, and reporting on time to reach FEF were included in the systematic review. Trials reporting on outcome according to type of feeding (exclusive HM vs. formula) were included in the meta-analysis. Fixed-effect or random-effects models were used as appropriate. Results were expressed as mean difference (MD) with 95% confidence interval (CI). Twenty-five studies were included in the systematic review. In the five studies recruiting exclusively HM-fed preterm infants, those treated with probiotics reached FEF approximately 3 days before controls (MD −3.15 days (95% CI −5.25/−1.05), p = 0.003). None of the two studies reporting on exclusively formula-fed infants showed any difference between infants receiving probiotics and controls in terms of FEF achievement. The limited number of included studies did not allow testing for other subgroup differences between HM and formula-fed infants. However, if confirmed in further studies, the 3-days reduction in time to achieve FEF in exclusively HM-fed preterm infants might have significant implications for their clinical management.

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“…Two studies found the probiotic group reached full feeds sooner and had an increased rate of feeding advancement [9,21]. In contrast, other studies found no difference in the time it took to reach full enteral feedings, the feeding ratio or feeding volume [26,29]. An additional study found no difference in average feeding volume in infants <1000 g but did encounter an increase when stratified to infants with a birthweight between 751-1000 g [8].…”

Section: Effect Of Probiotic Supplements On Enteral Feeding and Gi Tomentioning

confidence: 99%

Beneficial Effects of Probiotic Administration in Extremely Low Birthweight Infants: A Review

Beinlich

Logomarsino

2016

J. Nutr. Ther.

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The aim of this review was to evaluate the beneficial effects of probiotic supplementation on extremely low birthweight infants (birthweight <1000 g). Extremely low birthweight (ELBW) infants are the most vulnerable population in the neonatal intensive care unit (NICU). They are at the highest risk for necrotizing enterocolitis (NEC), sepsis, and inadequate nutrition due to their immature gastrointestinal (GI) function. Nutrition plays an important role in the future neurodevelopmental outcomes of these infants. Research methods for the review were conducted using PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL). In total, eight research studies evaluated the effect of probiotic use in ELBW infants: three studies assessed GI colonization, five studies assessed enteral feeding and GI tolerance, one study assessed growth, five studies assessed NEC, five studies assessed sepsis, and two studies assessed length of hospital stay. This review found the use of probiotics improved GI tolerance, weight gain and length of hospital stay in ELBW infants, but was unable to make conclusions on the effect of probiotic use on incidences of NEC and sepsis. More research is needed in ELBW infants before making probiotic supplementation a standard of care in this population.

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Probiotics supplementation increases intestinal blood flow velocity in extremely low birth weight preterm infants

Abstract: Probiotics administration significantly increases postprandial intestinal blood flow in extremely low birth weight preterm neonates when compared with the placebo group.

Cited by 20 publications

References 20 publications

Benefits of probiotics on enteral nutrition in preterm neonates: a systematic review

Benefits of probiotics on enteral nutrition in preterm neonates: a systematic review

Probiotics and Time to Achieve Full Enteral Feeding in Human Milk-Fed and Formula-Fed Preterm Infants: Systematic Review and Meta-Analysis

Beneficial Effects of Probiotic Administration in Extremely Low Birthweight Infants: A Review

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