Probiotics Supplementation on Cardiac Remodeling Following Myocardial Infarction: a Single-Center Double-Blind Clinical Study

Moludi, Jalal; Saiedi, Somaieh; Ebrahimi, Behzad; Alizadeh, Mohammad; Khajebishak, Yaser; Ghadimi, Sevda Saleh

doi:10.1007/s12265-020-10052-1

Cited by 39 publications

(27 citation statements)

References 35 publications

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“…The full texts of the remaining 21 studies were reviewed, and studies failing to meet the inclusion criteria, including no RCT design, unavailable data and studies non-conformity in terms of the outcome indices, were excluded. Finally, ten studies (12 arms) published in English met our inclusion criteria (Figure 1) (17,18,(22)(23)(24)(25)(26)(27)(28)(29).…”

Section: Literature Search and Screeningmentioning

confidence: 99%

“…Ten studies (12 arms) (17,18,(22)(23)(24)(25)(26)(27)(28)(29) observed the effect of microbiota-driven therapy on circulating TMAO level (Figure 4). There was an obvious heterogeneity among the included studies (I 2 = 63.0%, P = 0.172), and a randomeffect model was used to assess the effects of treatment.…”

Section: Effect Of Microbiota-driven Therapy On Circulating Tmao Levelmentioning

confidence: 99%

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Effects of Microbiota-Driven Therapy on Circulating Trimethylamine-N-Oxide Metabolism: A Systematic Review and Meta-Analysis

Miao

Chen

et al. 2021

Front. Cardiovasc. Med.

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Aim: This study was designed to systematically evaluate the effects of microbiota-driven therapy on decreasing TMAO and its related metabolites.Methods and Results: PubMed, EMBASE and Cochrane Library databases were searched (up to July 2021). Randomized controlled trials (RCTs), compared microbiota-driven therapy (prebiotics, probiotics, or synbiotics) with placebo on decreasing TMAO and its related metabolites, were eligible. Two researchers extracted the data independently and the disagreement was resolved by a third researcher. The risk of bias of included study was evaluated using Cochrane tool (RoB 2.0). Meta-analysis, meta-regression analysis and publication bias analysis were performed by RevMan 5.3 or Stata 12.0 software. Ten studies (12 arms) involving 342 patients (168 patients in the intervention group and 174 patients in the control group) were included. Compared with the control group, microbiota-driven therapy did not reduce circulating TMAO [SMD = −0.05, 95% CI (−0.36, 0.26), P = 0.749], choline [SMD = −0.34, 95% CI (−1.09, 0.41), P = 0.373], betaine aldehyde [SMD = −0.704, 95% CI (−1.789, 0.382), P = 0.204], and L-carnatine [SMD = −0.06, 95% CI (−0.38, 0.25), P = 0.692].Conclusion: Current evidence does not support that microbiota-driven treatment reduce circulating levels of TMAO, choline, betaine aldehyde, and L-carnitine. However, given the small sample size, this conclusion needs to be proved in the future.Systematic Review Registration: PROSPERO:CRD42019119107.

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Section: Literature Search and Screeningmentioning

confidence: 99%

Section: Effect Of Microbiota-driven Therapy On Circulating Tmao Levelmentioning

confidence: 99%

Effects of Microbiota-Driven Therapy on Circulating Trimethylamine-N-Oxide Metabolism: A Systematic Review and Meta-Analysis

Miao

Chen

et al. 2021

Front. Cardiovasc. Med.

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“…Dysbiosis of the gut microbiota has recently emerged as a novel target for the control of cardiac remodeling [ 126 ]. Gut microbiota composition is linked to cardiovascular diseases (CVD) through multiple mechanisms including (1) direct effects of microbial metabolites on atherosclerosis and thrombosis and (2) immune modulation by bacteria and their products [ 127 ].…”

Section: Pharmacological Approachesmentioning

confidence: 99%

Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction

Zhao

2020

Oxidative Medicine and Cellular Longevity

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Cardiac remodeling describes a series of structural and functional changes in the heart after myocardial infarction (MI). Adverse post-MI cardiac remodeling directly jeopardizes the recovery of cardiac functions and the survival rate in MI patients. Several classes of drugs are proven to be useful to reduce the mortality of MI patients. However, it is an ongoing challenge to prevent the adverse effects of cardiac remodeling. The present review aims to identify the pharmacological therapies from the existing clinical drugs for the treatment of adverse post-MI cardiac remodeling. Post-MI cardiac remodeling is a complex process involving ischemia/reperfusion, inflammation, cell death, and deposition of extracellular matrix (ECM). Thus, the present review included two parts: (1) to examine the basic pathophysiology in the cardiovascular system and the molecular basis of cardiac remodeling and (2) to identify the pathological aspects of cardiac remodeling and the potential of the existing pharmacotherapies. Ultimately, the present review highlights drug repositioning as a strategy to discover effective therapies from the existing drugs against post-MI cardiac remodeling.

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“…But various studies show the beneficial effects of probiotics on different types of chronic diseases, especially diseases associated with abnormal levels of TMAO [14e16]. In a study by Moludi et al, Probiotic supplementation significantly reduced the level of this metabolite in patients with myocardial infarction [17]. In another study, however, L. casei Shirota as a probiotic strain did not show a significant effect on TMAO levels in atherosclerotic patients [18].…”

Section: Introductionmentioning

confidence: 97%

“…Generally, some clinical trials have shown beneficial effects on TMAO levels in different populations [17,20]. But, some studies have not shown these beneficial effects [18,19].…”

Section: Introductionmentioning

confidence: 99%

Impact of probiotic supplementation on trimethylamine N-oxide (TMAO) in humans: A systematic review and meta-analysis of randomized controlled trials

Sohouli¹,

Ozovanu²,

Fatahi³

et al. 2022

Clinical Nutrition ESPEN

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Probiotics Supplementation on Cardiac Remodeling Following Myocardial Infarction: a Single-Center Double-Blind Clinical Study

Cited by 39 publications

References 35 publications

Effects of Microbiota-Driven Therapy on Circulating Trimethylamine-N-Oxide Metabolism: A Systematic Review and Meta-Analysis

Effects of Microbiota-Driven Therapy on Circulating Trimethylamine-N-Oxide Metabolism: A Systematic Review and Meta-Analysis

Pharmacological Modulation of Cardiac Remodeling after Myocardial Infarction

Impact of probiotic supplementation on trimethylamine N-oxide (TMAO) in humans: A systematic review and meta-analysis of randomized controlled trials

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