Problem of J-chain of immunoglobulins

Климович, В. Б.; Самойлович, М. П.; Klimovich, Boris

doi:10.1134/s0022093008020023

Cited by 17 publications

(20 citation statements)

References 93 publications

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“…Next to IgM, IgD is a commonly found immunoglobulin in teleost [81], but till now this isotype is never correlated to mucosal immunity. Although, in sheepshead [82,83] and carp [42] differences were observed between serum and mucus Ig, molecular evidence was never found for different IgM subtypes. In carp, a mAb could be selected reacting with the H chain of mucus and not of serum IgM.…”

Section: Mucosal Immunoglobulinmentioning

confidence: 53%

“…In sheepshead (Archosargus probatocephalus), a noncovalent dimer of covalent dimeric subunits has been described associated to a 95 kDa secretory componentlike protein [82,83], but this was not found in bile of the same species and also never observed in other species. In teleost fish a J-chain is never found while this IgA or IgM-joining protein is present in all vertebrates, including cartilaginous fish [83]. Nevertheless, it can be concluded that teleosts have a mucosal immune system because intravenous administration of radiolabeled Ig never reached the mucosal secretions [84] and therefore the Ig in mucosal secretions must be the result of local synthesis [42,76,84].…”

Section: Mucosal Immunoglobulinmentioning

confidence: 95%

“…This mAb could be used to detect specific plasma cells in gut and gills after mucosal immunization and was immunoreactive with bile ducts and capillaries in liver and with skin epithelial cells, just the sites were mucosal Ig can be expected [42]. In sheepshead (Archosargus probatocephalus), a noncovalent dimer of covalent dimeric subunits has been described associated to a 95 kDa secretory componentlike protein [82,83], but this was not found in bile of the same species and also never observed in other species. In teleost fish a J-chain is never found while this IgA or IgM-joining protein is present in all vertebrates, including cartilaginous fish [83].…”

Section: Mucosal Immunoglobulinmentioning

confidence: 97%

“…Therefore it is postulated [95,97] that the J-chain has to be present in teleost as it is in cartilaginous fish. However, it is also suggested that the mammalian J-chain does not interact directly with the pIgR, but merely creates the necessary conformational site for binding with the pIgR [83]. On the other hand the J-chain of mammals, birds and amphibians are all able to polymerize human IgA while the J-chain of nurse shark is not, probably because the highly conserved J-chain region for pIgR interaction in tetrapods is lacking in cartilaginous fish [94].…”

Section: The Polymeric Ig Receptor (Pigr)mentioning

confidence: 98%

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Teleost intestinal immunology

Rombout¹,

Abelli²,

Picchietti³

et al. 2011

Fish & Shellfish Immunology

510

284

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Teleosts clearly have a more diffuse gut associated lymphoid system, which is morphological and functional clearly different from the mammalian GALT. All immune cells necessary for a local immune response are abundantly present in the gut mucosa of the species studied and local immune responses can be monitored after intestinal immunization. Fish do not produce IgA, but a special mucosal IgM isotype seems to be secreted and may (partly) be the recently described IgZ/IgT. Fish produce a pIgR in their mucosal tissues but it is smaller (2 ILD) than the 4-5 ILD pIgR of higher vertebrates. Whether teleost pIgR is transcytosed and cleaved off in the same way needs further investigation, especially because a secretory component (SC) is only reported in one species. Teleosts also have high numbers of IEL, most of them are CD3-ɛ+/CD8-α+ and have cytotoxic and/or regulatory function. Possibly many of these cells are TCRγδ cells and they may be involved in the oral tolerance induction observed in fish. Innate immune cells can be observed in the teleost gut from first feeding onwards, but B cells appear much later in mucosal compartments compared to systemic sites. Conspicuous is the very early presence of putative T cells or their precursors in the fish gut, which together with the rag-1 expression of intestinal lymphoid cells may be an indication for an extra-thymic development of certain T cells. Teleosts can develop enteritis in their antigen transporting second gut segment and epithelial cells, IEL and eosinophils/basophils seem to play a crucial role in this intestinal inflammation model. Teleost intestine can be exploited for oral vaccination strategies and probiotic immune stimulation. A variety of encapsulation methods, to protect vaccines against degradation in the foregut, are reported with promising results but in most cases they appear not to be cost effective yet. Microbiota in fish are clearly different from terrestrial animals. In the past decade a fast increasing number of papers is dedicated to the oral administration of a variety of probiotics that can have a strong health beneficial effect, but much more attention has to be paid to the immune mechanisms behind these effects. The recent development of gnotobiotic fish models may be very helpful to study the immune effects of microbiota and probiotics in teleosts.

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Section: Mucosal Immunoglobulinmentioning

confidence: 53%

Section: Mucosal Immunoglobulinmentioning

confidence: 95%

Section: Mucosal Immunoglobulinmentioning

confidence: 97%

Section: The Polymeric Ig Receptor (Pigr)mentioning

confidence: 98%

See 2 more Smart Citations

Teleost intestinal immunology

Rombout¹,

Abelli²,

Picchietti³

et al. 2011

Fish & Shellfish Immunology

510

284

View full text Add to dashboard Cite

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“…Immunoglobulin M (IgM) is the first antibody that is produced in the immune system and provides a crucial first line of defense for the immune system [8,9]. Previous reports had confirmed that IgM levels would increased with environmental temperature in rainbow trout [10] and Nile tilapia [11].…”

Section: Introductionmentioning

confidence: 91%

Immunoglobulin M gene expression analysis of orange-spotted grouper, Epinephelus coioides, following heat shock and Vibrio alginolyticus challenge

Cui

Zhang

Yao

et al. 2010

Fish & Shellfish Immunology

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Noncoordinate expression of J‐chain and Blimp‐1 define nurse shark plasma cell populations during ontogeny

2013

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Summary Blimp-1 is the master regulator of plasma cell development, controlling genes such as J-chain and secretory Ig heavy chain. However, some mammalian plasma cells do not express J-chain, and mammalian B1 cells secrete “natural” IgM antibodies without upregulating Blimp-1. While these results have been controversial in mammalian systems, here we describe subsets of normally occurring Blimp-1- antibody secreting cells in nurse sharks, found in lymphoid tissues at all ontogenic stages. Sharks naturally produce large amounts of both pentameric (classically ‘19S’) and monomeric (classically ‘7S’) IgM, the latter an indicator of adaptive immunity. Consistent with the mammalian paradigm, shark Blimp-1 is expressed in splenic 7S IgM-secreting cells, though rarely detected in the J-chain+ cells producing 19S IgM. Although IgM transcript levels are lower in J-chain+ cells, these cells nevertheless secrete 19S IgM in the absence of Blimp-1, as demonstrated by ELISPOT and metabolic labeling. Additionally, cells in the shark bone marrow equivalent (epigonal) are Blimp-1-. Our data suggest that, in sharks, 19S-secreting cells and other secreting memory B cells in the epigonal can be maintained for long periods without Blimp-1, but like in mammals, Blimp-1 is required for terminating the B cell program following an adaptive immune response in the spleen.

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Problem of J-chain of immunoglobulins

Cited by 17 publications

References 93 publications

Teleost intestinal immunology

Teleost intestinal immunology

Immunoglobulin M gene expression analysis of orange-spotted grouper, Epinephelus coioides, following heat shock and Vibrio alginolyticus challenge

Noncoordinate expression of J‐chain and Blimp‐1 define nurse shark plasma cell populations during ontogeny

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