Problem of safety in nanoparticle mass production and its solution by means of advanced scanning electron microscopy

Maksimov, Serguei Kirillovich; Maksimov, K. S.

doi:10.1088/1742-6596/291/1/012014

Cited by 1 publication

(6 citation statements)

References 9 publications

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“…Joint use of the methods suggested in this paper and developed computer methods of SEM image processing provides the habit determination and the notice in this paragraph doesn't disprove the suggested methods of habit determination but only specifies practice of their use [4,29,30].…”

Section: a Focusing Plane Of The Parallel Beam And Initial Focusingmentioning

confidence: 89%

“…Following the sequence of operations allows transforming an intensity distribution in an object image into its 3D image in the real space (in the object space) that reflects to true sizes and a habit of objects and corresponds to it in a maximally possible degree [4,29,30]: 1) To focus a convergent beam on ZOHP.…”

Section: Methods Of Habit Determination Founded On the Use Of Convergmentioning

confidence: 99%

“…Therefore particles with the same sizes and produced in the same process can be of different structural-morphological parameters and, naturally, of different catalytic activity. Hence all technologies of nanoparticles are potentially binary; creation of a necessary product may be always accompanied by formation of a dangerous co-product [3,4]. This peculiarity of nanotechnologies can be, for lack of another term, named "ambivalence".…”

Section: Premises and Essence Of The Problemmentioning

confidence: 99%

“…Inspection of a habit of a single nanoparticle is a prerogative of microscopic methods possessing of spatial resolution necessary for measurements in nanoworld: the scanning probe microscopy (SPM), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) [4]. These methods can be divided into two groups: SPM and TEM belong to the first, they have been developed as techniques of obtaining of the unique information in the atomic level [18,19], SEM belongs to the second, since it has been intended, primarily, for mapping of the object massifs [20].…”

Section: Microscopy In Nanoparticles Inspectionmentioning

confidence: 99%

“…Safety guarantee in mass production of nanoparticles is possible only if the structure and habit are under control, and both these kind of control are time-consuming. Habit inspection demands use of at least 2 micrographs and their further coprocessing [4,29,30]. Structure inspection founded on the use of electron diffraction patterns reflecting different projections [31].…”

Section: General Principles Of Organization Of Outgoing Production Inmentioning

confidence: 99%

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As Could We Assure Safety in Large-Scale Manufacturing of Nanoparticles for the Biomedical Use

Maksimov¹,

Maksimov²,

Soukhov³

2011

JBNB

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Nanoparticles provide great advantages but also great risks. Risks associating with nanoparticles are the problem of all technologies, but they increase in many times in nanotechnologies. Adequate methods of outgoing production inspection are necessary to solve the problem of risks, and the inspection must be based on the safety standard. Existing safety standard results from a principle of “maximum permissible concentrations or MPC”. This principle is not applicable to nanoparticles, but a safety standard reflecting risks inherent in nanoparticles doesn’t exist. Essence of the risks is illustrated by the example from pharmacology, since its safety assurance is conceptually based on MPC and it has already come against this problem. Possible formula of safety standard for nanoparticles is reflected in many publications, but conventional inspection methods cannot provide its realization, and this gap is an obstacle to assumption of similar formulas. Therefore the development of nanoparticle industry as a whole (also development of the pharmacology in particular) is impossible without the creation of an adequate inspection method. There are suggested new inspection methods founded on the new physical principle and satisfying to the adequate safety standard for nanoparticles. These methods demonstrate that creation of the adequate safety standard and the outgoing production inspection in a large-scale manufacturing of nanoparticles are the solvable problems. However there is a great distance between the physical principle and its hardware realization, and a transition from the principle to the hardware demands great intellectual and material costs. Therefore it is desirable to call attention of the public at large to the necessity of urgent expansions of investigations associated with outgoing inspections in nanoparticles technologies. It is necessary also to attract attention, first, of representatives of state structures controlling approvals of the adequate safety standard to this problem, since it is impossible to compel producers providing the safety without the similar standard, and, second, of leaders of pharmacological industry, since their industry already entered into the nanotechnology era, and they have taken an interest in a forthcoming development of inspection methods

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Section: a Focusing Plane Of The Parallel Beam And Initial Focusingmentioning

confidence: 89%

Section: Methods Of Habit Determination Founded On the Use Of Convergmentioning

confidence: 99%

Section: Premises and Essence Of The Problemmentioning

confidence: 99%

Section: Microscopy In Nanoparticles Inspectionmentioning

confidence: 99%

Section: General Principles Of Organization Of Outgoing Production Inmentioning

confidence: 99%

See 3 more Smart Citations

As Could We Assure Safety in Large-Scale Manufacturing of Nanoparticles for the Biomedical Use

Maksimov¹,

Maksimov²,

Soukhov³

2011

JBNB

View full text Add to dashboard Cite

show abstract

Problem of safety in nanoparticle mass production and its solution by means of advanced scanning electron microscopy

Cited by 1 publication

References 9 publications

As Could We Assure Safety in Large-Scale Manufacturing of Nanoparticles for the Biomedical Use

As Could We Assure Safety in Large-Scale Manufacturing of Nanoparticles for the Biomedical Use

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