Problem solved: erectile dysfunction (ED) = early death (ED)

Jackson, Graham

doi:10.1111/j.1742-1241.2010.02419.x

Cited by 7 publications

(3 citation statements)

References 38 publications

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“…In addition to the mounting evidence confirming that ED and CV disease are manifestations of generalized endothelial dysfunction in different vascular beds [17–28], ED has been shown to predict atherosclerotic CV events in men without symptomatic CV disease [29–46]. Increased CV disease mortality has been highlighted in a recent review and in editorial comments [47,48]. A mortality hazard ratio (HR) of 1.43 (95% confidence interval [CI] 1.00, 2.05) has been reported in men with moderate or complete ED compared with men with or without minimal ED [49].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Mortality in Men with Erectile Dysfunction: Increased Risk But Not Inevitable

Chew

Gibson

Sanfilippo

et al. 2011

The Journal of Sexual Medicine

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Introduction It is unclear whether men with erectile dysfunction (ED) ultimately die of cardiovascular (CV) causes. Aim This study examined the causes of death in men with ED and their risk of CV death. Methods Based on statutory death registrations and hospital morbidity data, the risk of CV death in men with ED in a linked-data study was assessed against the CV mortality risk in a reference male population. Main Outcome Measures Deaths from CV causes as proportions of all deaths. Age-specific rate, mortality rate ratio (MRR), standardized mortality rate ratio (SMRR), and adjusted hazard ratio (HR). Results CV mortality was 4.0%. Compared with the reference population, the risk of CV death was higher in men with ED (SMRR 2.2; 95% confidence interval [CI] 1.6, 3.0). Risk of CV mortality was higher in men with CV disease prior to ED (adjusted HR 1.7; 95% CI 1.1, 2.6) or with history of hospital admissions for CV events (adjusted HR 2.2; 95% CI 1.3, 3.8), compared with those without the respective history. MRR was significantly increased in the 40–69 years age group (MRR 4.1; 95% CI 3.2, 5.2). The median time interval between manifestation of ED and CV death was 10.0 years. A greater proportion of deaths from oncological than from CV causes (25.0% vs. 10.8%) occurred within the first 5 years of the manifestation of ED. Conclusions Although the risk of CV mortality is greater in men with ED, almost as many men die of oncological as of CV causes, with a higher proportion of oncological deaths occurring sooner subsequent to the first manifestation of ED.

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Section: Introductionmentioning

confidence: 99%

Cardiovascular Mortality in Men with Erectile Dysfunction: Increased Risk But Not Inevitable

Chew

Gibson

Sanfilippo

et al. 2011

The Journal of Sexual Medicine

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“…Cardiovascular workup in patients with ED and cardiovascular risk factors may both enable early detection of patients at increased risk for cardiovascular events and provide improvement of symptoms related to vascular ED [3,13]. Therefore, patients with symptoms of ED and the presence of cardiovascular risk factors should be referred for arterial workup.…”

Section: Arterial Workupmentioning

confidence: 99%

Interdisciplinary options for diagnosis and treatment of organic erectile dysfunction

et al. 2015

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Erectile dysfunction (ED) is a frequently encountered symptom in primary care and may be a clinical challenge requiring intensive interdisciplinary collaboration. The pathogenesis of organic ED may frequently be multifactorial. However, vascular or endocrine disorders as well as drug treatments are among its leading causes. More recently, ED has been identified as an important sentinel symptom for systemic cardiovascular disease. The purpose of the present mini-review is to provide an interdisciplinary overview on current diagnostic and treatment modalities for patients suffering from ED.

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“…5 It is associated with a higher risk of suffering from heart disease 6 and increased cardiovascular-related mortality. 7 In 2014, PE (lifelong and acquired) was defined by the International Society of Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation as an ejaculation that always or nearly always occurs prior to or within about 1 minute of vaginal penetration (lifelong PE), or a clinically significant and bothersome reduction in latency time, often for about 3 minutes or less (acquired PE), and the inability to delay ejaculation in all or nearly all vaginal penetrations, thereby resulting in negative personal consequences, such as distress, bother, frustration, and/ or the avoidance of sexual intimacy. 8,9 The lack of research studies on the relevance of ED and PE, compounded by the fact that many patients and health practitioners find it difficult to address problems of a sexual nature during consultations (due to cultural, religious, or moral issues), means that existing epidemiologic data are very scarce.…”

Section: Introductionmentioning

confidence: 99%

Opinions, Attitudes, and Perceptions in Relation to Erectile Dysfunction and Premature Ejaculation in the Undiagnosed Spanish Male Population. Results of the PANDORA Project

Prieto-Castro

Puigvert-Martínez²,

Artigas-Feliu

et al. 2020

The Journal of Sexual Medicine

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Background: Approximately 43% of Spanish men report experiencing premature ejaculation (PE) at some point in their lives and 12.1% suffer from erectile dysfunction (ED), of whom only 16.5% have seen a doctor. Despite this, ED and PE remain undiagnosed among a supposedly healthy segment of the population. Aim: To assess the general knowledge of a representative population of healthy Spanish males of the symptoms, treatment, and expectations related to ED and PE. Methods: This was a descriptive study based on an online questionnaire in which 2,515 males aged 25e75 years with no history of ED and/or PE presented their perception of aspects related to symptoms, diagnosis, treatment, and expectations in ED and PE. Main Outcome Measures: The study provided an evaluation of the knowledge, attitude, and underdiagnosis of ED and/or PE in healthy males and the approach taken by urology specialists and other disciplines. Results: The survey was completed by 2,515 healthy males, including over 80% of those who had completed secondary or higher education. 60% of the sample had never seen a urologist and 59% and 62% of the participating men responded correctly to the statements about PE and ED, respectively. Their lack of knowledge of the therapeutic alternatives was clear (74% and 76% of the panel were unaware of the existence of effective treatments for ED and PE, respectively). Despite the initiative shown by some participants in seeking information about each condition (10.3% for ED; 16.7% for PE), only 4.7% of them had been questioned about ED by a medical practitioner (1.9% for PE). The underdiagnosis rate stood at 3.5% for ED (5.6% participants >65 years) and at about 10% for PE. Clinical Implications: These results will represent a point of departure for establishing some recommendations to improve the detection and treatment of these disorders. Strengths & Limitations: This is the first study of its kind in Spain to analyze the underdiagnosis of ED and/or PE inferred from data reported by a population of healthy males. Screening for ED was performed with a validated questionnaire. However, the rest of the research was conducted using adaptations of validated questionnaires or a self-designed questionnaire based on and in consultation with a group of experienced andrologists. Conclusion: People need to have greater knowledge of both the conditions and the related false myths to make sure that they are familiar with the existence of drug treatments and socio-sanitary interventions. Primary care physicians and urologists should also be more proactive in routine visits in order to achieve better management of ED and PE. Prieto-Castro R, Puigvert-Martínez AM, Artigas-Feliu R, et al. Opinions, Attitudes, and Perceptions in Relation to Erectile Dysfunction and Premature Ejaculation in the Undiagnosed Spanish Male Population. Results of the PANDORA Project.

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Problem solved: erectile dysfunction (ED) = early death (ED)

Cited by 7 publications

References 38 publications

Cardiovascular Mortality in Men with Erectile Dysfunction: Increased Risk But Not Inevitable

Cardiovascular Mortality in Men with Erectile Dysfunction: Increased Risk But Not Inevitable

Interdisciplinary options for diagnosis and treatment of organic erectile dysfunction

Opinions, Attitudes, and Perceptions in Relation to Erectile Dysfunction and Premature Ejaculation in the Undiagnosed Spanish Male Population. Results of the PANDORA Project

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