ObjectiveThis study examined the long‐term effects of the COVID‐19 pandemic on adolescents' substance use, digital media use, and symptoms of internet, gaming, and social media addiction.MethodA nationally representative longitudinal cohort of 1665 Israeli teens and preteens, aged 9–16, completed questionnaires assessing substance use prevalence, daily screen time, symptoms of media addiction, and potential risk and protective factors. Data were collected before the pandemic (October 2019), after the second wave lockdown (November 2020), and after the fifth wave (April 2022) in Israel.ResultsThe analysis documented significant increases in substance use, daily screen time, and social media addiction indices over time. Gratitude, life satisfaction, positive emotions, future orientation, grit, and secure attachment emerged as significant protective factors. Sensation‐seeking, negative emotions, and mental health symptoms were identified as risk factors.ConclusionsThese findings highlight the importance of educational and public mental health services in addressing the pandemic's long‐term impact on the mental health and addictive behaviors of adolescents. They also emphasize the significance of enhancing protective factors and reducing risk factors to effectively mitigate substance and digital media abuse among adolescents.