The present study used data from the 1991 and 1992 Drug Use Forecasting projects and the 1990 census data to test the hypothesis that certain “structural disadvantage factors” identified by social conflict theory (Goode, 1997, 1999) contribute to explaining arrestees' use of cocaine and/or opiates. Using hierarchical nonlinear modeling techniques, this study explored whether social-control factors and demographic factors were effective predictors of arrestees' drug use. It also questioned whether the effects of such factors on drug use varied with the degree of structural disadvantage of the arrestees' residential districts. Overall, the study resulted in support for a link between a group of hard-drug users and contextual factors of structural disadvantage.