Problems associated with the use of cycloheximide to distinguish between animal drug residues bound to protein and those incorporated into protein

Wislocki, Peter G.; Fiorentini, Karen M.; Alvaro, Raul; Lu, Anthony Y. H.; Wolf, Frank J.

doi:10.1016/s0278-6915(82)80106-3

Food and Chemical Toxicology

1982

DOI: 10.1016/s0278-6915(82)80106-3

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Problems associated with the use of cycloheximide to distinguish between animal drug residues bound to protein and those incorporated into protein

Peter G. Wislocki¹,

Karen M. Fiorentini²,

Raul Alvaro³

et al.

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Cited by 3 publications

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A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues

Delatour¹,

Garnier²,

Benoît³

et al. 1984

Vet Pharm & Therapeutics

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The possible correlations between embryotoxicity, plasma kinetics of toxic metabolites and covalent binding of metabolites to foetal tissues were studied using two drugs, albendazole and oxfendazole. In the rat, the metabolic inhibitor, SKF-525A, induced changes in embryotoxicity which were well correlated with plasma levels of identified embryotoxic metabolites, but not with the levels of foetal tissue bound drug metabolites.

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A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues

Delatour¹,

Garnier²,

Benoît³

et al. 1984

Vet Pharm & Therapeutics

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show abstract

Tissue Drug Residues and their Toxicological Significance

Wislocki

Chiu

et al. 1987

Drug Metabolism Reviews

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Formation and Biological Evaluation of Ronidazole Bound Residues

Wislocki

1990

Drug Metabolism Reviews

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Problems associated with the use of cycloheximide to distinguish between animal drug residues bound to protein and those incorporated into protein

Cited by 3 publications

References 2 publications

A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues

A correlation of toxicity of albendazole and oxfendazole with their free metabolites and bound residues

Tissue Drug Residues and their Toxicological Significance

Formation and Biological Evaluation of Ronidazole Bound Residues

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