Problems in pharmaceutical compounding of eye-drops with cyclosporine A

Wolska, Eliza; Gajewska, M; Sznitowska, Małgorzata

doi:10.32383/farmpol/115751

Cited by 2 publications

(4 citation statements)

References 9 publications

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“…For this purpose, physical factors such as higher temperature, relative humidity, and UV radiation were applied. The storage conditions of 40 °C/75%RH and 14 days were chosen, as they are recommended for preliminary testing of new drug formulations [ 6 , 16 ]. Additionally, the impact of UV radiation on the tested lozenges was examined [ 9 ].…”

Section: Resultsmentioning

confidence: 99%

“…The propolis lozenges were subjected to stress conditions by storing them in an incubator with controlled temperature and relative humidity. The lozenges were placed on Petri dishes and stored at a temperature of 40 °C (±2 °C) and a relative humidity (RH) of 75% (±5%) for a duration of 14 days [ 6 , 16 ]. The incubator used for this purpose was a Memmert company air circulation incubator (Schwabach, Germany) which maintained constant parameters.…”

Section: Methodsmentioning

confidence: 99%

“…The propolis lozenges were subjected to UVA (315–400 nm) radiation [ 8 , 16 ]. The irradiation was conducted using a Medison 250 lamp manufactured by Schulze & Bohm (Brühl, Germany).…”

Section: Methodsmentioning

confidence: 99%

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Propolis as a Cariostatic Agent in Lozenges and Impact of Storage Conditions on the Stability of Propolis

et al. 2023

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Propolis is known as a source of compounds with strong antibacterial activity. Due to the antibacterial effect against streptococci of the oral cavity, it seems to be a useful agent in decreasing the accumulation of dental plaque. It is rich in polyphenols which are responsible for a beneficial impact on the oral microbiota and antibacterial effect. The aim of the study was to evaluate the antibacterial effect of Polish propolis against cariogenic bacteria. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined on cariogenic streptococci related to the occurrence of dental caries. Lozenges based on xylitol, glycerin, gelatin, water, and ethanol extract of propolis (EEP) were prepared. The effect of prepared lozenges on cariogenic bacteria was assessed. Propolis was compared to chlorhexidine which is used in dentistry as the gold standard. In addition, the prepared propolis formulation was stored under stress conditions to assess the influence of physical conditions (i.e., temperature, relative humidity, and UV radiation). In the experiment, thermal analyses were also performed to evaluate the compatibility of propolis with the substrate used to create the base of lozenges. The observed antibacterial effect of propolis and prepared lozenges with EEP may suggest directing subsequent research on prophylactic and therapeutic properties decreasing the accumulation of dental plaque. Therefore, it is worth highlighting that propolis may play an important role in the management of dental health and bring advantages in preventing periodontal diseases and caries as well as dental plaque. The colorimetric analyses carried out in the CIE L*a*b* system, microscopic examinations, and TGA/DTG/c-DTA measurements indicate the unfavorable effect of the tested storage conditions on the lozenges with propolis. This fact is particularly evident for lozenges stored under stress conditions, i.e., 40 °C/75% RH/14 days, and lozenges exposed to UVA radiation for 60 min. In addition, the obtained thermograms of the tested samples indicate the thermal compatibility of the ingredients used to create the formulation of lozenges.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Propolis as a Cariostatic Agent in Lozenges and Impact of Storage Conditions on the Stability of Propolis

et al. 2023

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“…Conducting studies to separate and identify degradation products is essential to testing the stability of active substances. Cyclosporine A is a widely studied example of such a substance [ 140 ]. Table 7 summarizes the analytical tools used to assess the chemical stability of Cyclosporine A presented in the literature.…”

Section: Methods For Assessing the Stability Of Active Substancesmentioning

confidence: 99%

Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

Rykowska,

Michałkiewicz,

Nowak

et al. 2024

Molecules

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The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses. It discusses the types of drugs embedded into contact lenses, the various polymeric materials used in their production, methods for assessing the mechanical properties of polymers, and techniques for studying drug release kinetics. The article also explores strategies for investigating the stability of active substances released from contact lenses. It specifically emphasizes the production of soft contact lenses modified with Cyclosporine A (CyA) for the topical treatment of specific ocular conditions. The review pays attention to methods for monitoring the stability of Cyclosporine A within the discussed DDS, as well as investigating the influence of polymer matrix type on the stability and release of CyA.

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Problems in pharmaceutical compounding of eye-drops with cyclosporine A

Cited by 2 publications

References 9 publications

Propolis as a Cariostatic Agent in Lozenges and Impact of Storage Conditions on the Stability of Propolis

Propolis as a Cariostatic Agent in Lozenges and Impact of Storage Conditions on the Stability of Propolis

Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

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