Problems of chronic manganese poisoning on the basis of investigations of workers at a manganese alloy foundry

Jonderko, G; Kujawska, A; Langauer-Lewowicka, H

doi:10.1007/bf00539137

Cited by 20 publications

(11 citation statements)

References 12 publications

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“…In an early study carried out by Jonderko et al (1971) on a group of active workers from a ferromanganese foundry with high serum Mn levels, who were removed from exposure, most showed no change over a 2-year period, 13.5% showed improvement, and 24.3% presented some form of health deterioration as measured by subjective symptom reporting and neurological examination. More recently, long-term effects of manganese following cessation of exposure have been examined among Chilean miners, who had not been exposed over the past 5 years (Hochberg et al, 1996).…”

Section: Workplace Studiesmentioning

confidence: 98%

Neurotoxic Effects of Low Level Exposure to Manganese in Human Populations

Mergler

1999

Environmental Research

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Section: Workplace Studiesmentioning

confidence: 98%

Neurotoxic Effects of Low Level Exposure to Manganese in Human Populations

Mergler

1999

Environmental Research

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“…The progression of neurological symptoms of manganism, documented in five alloy-workers 9-10 years after cessation of exposure, revealed continuing deterioration in gait, speed of foot tapping, rigidity, and handwriting [Huang et al, 1993]. In other studies of workers with high exposure who were only mildly or non-symptomatic while exposed, neurological signs developed several months after cessation of exposure [Penalver, 1955;Rodier, 1955;Jonderko et al, 1971;Meco et al, 1994]. In contrast, recovery from neurological signs was reported for intoxicated workers after treatment with CaNa 2 EDTA [Whitlock et al, 1966;Discalzi et al, 2000;Herrero Hernandez et al, 2006].…”

Section: Introductionmentioning

confidence: 98%

Neurobehavioral functioning after cessation of manganese exposure: A follow‐up after 14 years

Bouchard

Mergler

Baldwin

et al. 2006

American J Industrial Med

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“…Some studies showed that Mn in blood may interact with alcohol use disorders, accentuating neuropsychiatric symptoms [19,20]. Another study suggested that a higher Mn concentration in workers was related with alcoholism [17]. In this present study, 69.5% workers had alcohol drinking habit, which was probably caused by heavy physical labor and over stress.…”

Section: Discussionmentioning

confidence: 44%

“…For example, rendered Mn exposed individuals at higher risk for Parkinsonism [16]. Meanwhile, the Jordenko’s early survey showed that the serum ALT and AST levels in Mn alloy foundry workers had significant difference compared to the control group [17]. Another recent report described that workers under Mn exposure condition had higher ALT levels and complained more self-conscious symptoms [18].…”

Section: Discussionmentioning

confidence: 99%

Interaction of occupational manganese exposure and alcohol drinking aggravates the increase of liver enzyme concentrations from a cross-sectional study in China

Deng

Liu

et al. 2013

Environ Health

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BackgroundOver exposure to manganese (Mn) can damage the human central nervous system and potentially cause liver toxicity. Alcohol drinking is also one of the well-known harmful factors to hepatic organism. The interaction between Mn exposure and alcohol consumption to liver function was investigated in this study.MethodsA total of 1112 on-the-spot workers were included in the cross-sectional survey from a large scale of manganese exposed workers healthy cohort (MEWHC) in a ferro-manganese refinery company. A questionnaire was used to collect the demographic information, occupational history, and alcohol drinking habits. Occupational health examination was carried out for each worker. The five key serum indices, including total bilirubin (TBILI), direct bilirubin (DBILI), indirect bilirubin (IBILI), alanine transaminase (ALT), and aspartate transaminase (AST), were determined to evaluate the liver function of each subject.ResultsWorkers exposed to high levels of Mn had significantly elevated serum concentrations of liver enzymes (DBILI: 3.84±1.20 μmol/L, ALT: 27.04±19.12 IU/L, and AST: 29.96±16.68 IU/L), when compared to those in the low-exposure group (DBIL: 3.54±0.85 μmol/L, ALT: 20.38±10.97 IU/L, and AST: 26.39±8.07 IU/L), all P<0.01. These serum indices had a significantly increasing trend with the elevation of Mn exposure level (Ptrend <0.01). In addition, the workers with alcohol drinking also showed higher concentrations of liver enzymes than those non-drinkers, especially, and there was significant interaction between Mn exposure and alcohol consumption in terms of these three indices (P<0.001).ConclusionsOccupational exposure to Mn can lead to a dose-dependent increase of liver enzyme concentrations, and interact with alcohol drinking to potentially aggravate the liver damage. It will be important for Mn exposed workers to control drinking and also assess liver function in the occupational health examination.

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Problems of chronic manganese poisoning on the basis of investigations of workers at a manganese alloy foundry

Cited by 20 publications

References 12 publications

Neurotoxic Effects of Low Level Exposure to Manganese in Human Populations

Neurotoxic Effects of Low Level Exposure to Manganese in Human Populations

Neurobehavioral functioning after cessation of manganese exposure: A follow‐up after 14 years

Interaction of occupational manganese exposure and alcohol drinking aggravates the increase of liver enzyme concentrations from a cross-sectional study in China

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