Problems of diagnosis and treatment of Connshing syndrome

Abstract

Despite the fact that it has been almost 50 years since the first description of aldosterone-cortisol-producing adrenal adenomas (Connshing syndrome), there are still many unresolved issues regarding the diagnosis and treatment of this condition. The presented clinical case confirms the complexity of recognizing this disease due to the frequent absence of its manifesting clinical symptoms and the lack of information acquired from standard laboratory tests. In these cases, the method of comparative selective venous blood sampling from the adrenal glands plays a significant role in the differential diagnosis of rare forms of primary hyperaldosteronism. Analysis of clinical cases presented in the scientific literature from 2000 to 2023 showed that partial adrenalectomy is the method of choice for surgical treatment of this pathology, which is associated with minimal risk of postoperative complications.