Problems of Fibrin Adhesion to Nerves

Comparative Analysis of Biomechanical Performance of Available “Nerve Glues”

“…2 Herter further examined the question of adhesions and found that thrombin, factor XIII, and fibronectin all actually induced fibrosis. 17 The study of Sames et al that showed good nerve regeneration with fibrin glue when the nerves stayed together also demonstrated a 20% dehiscence rate. 4 Maragh et al found faster conduction velocities and higher peak amplitudes in rat sciatic nerves repaired with suture compared with Tisseel.…”