Problems of infection with &lt;i&gt;Neisseria gonorrhoeae&lt;/i&gt;

Walthoffen, Szymon Walter de

doi:10.26444/monz/132804

Cited by 2 publications

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“…Neisseria gonorrhoeae is the etiological agent of gonorrhea which remains a major public health problem. According to the World Health Organization (WHO), there were 87 million cases of gonorrhea worldwide in 2016 (Unemo et al 2017;Walter de Walthoffen 2021). Gonorrhea often occurs together with other sexually transmitted diseases (Mlynarczyk-Bonikowska et al 2014;Skulska et al 2015;Młynarczyk-Bonikowska et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Penicillinase plasmid Australia type in Neisseria gonorrhoeae isolated in Poland

Walthoffen

2022

Arch Microbiol

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Purpose Neisseria gonorrhoeae is an etiological agent of gonorrhea which remains a major public health problem the mechanisms that determine resistance to drugs of the beta-lactam class, which are recommended for the treatment of gonorrhea, are currently the most important problem in its treatment. Chromosomal mutations are responsible for resistance to ceftriaxone and cefepime. The possibility of mutations in the gene encoding beta-lactamase (blaTEM) in the penicillinase plasmid may also turn out to be a serious threat. Methods The occurrence of resistance encoded on penicillinase plasmid has been investigated. For this purpose, the susceptibility of bacteria was determined and the gene for resistance to beta-lactams as well as the plasmids themselves was typed. Results Of the 333 strains tested, 21 (6.3%) had the beta-lactamase gene and produced penicillinase. Two of the beta-lactamase: TEM-1 and TEM-135 occurred among the tested strains of N. gonorrhoeae. Most of the known penicillinase plasmid types of N. gonorrhoeae were demonstrated: the Asian, the African, the Toronto/Rio plasmids and Australian variants. Conclusions In the first 3 years, TEM-1 beta-lactamases dominated in N. gonorrhoeae, which were replaced by TEM-135 in the following years of the study. Not all molecular methods are capable of varying the types of penicillinase plasmids. A particularly noteworthy observation is the fact that the Australia-type of penicillinase plasmid (3270 bp) was identified for the first time in Europe, and the second time in the world.

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Section: Introductionmentioning

confidence: 99%

Penicillinase plasmid Australia type in Neisseria gonorrhoeae isolated in Poland

Walthoffen

2022

Arch Microbiol

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“…Neisseria gonorrhoeae is the etiological agent of gonorrhea which remains a major public health problem. According to the World Health Organization (WHO), there were 87 million cases of gonorrhea worldwide in 2016 (Unemo et al 2017, Walter de Walthoffen 2021. Gonorrhea often occurs together with other sexually transmitted diseases (Mlynarczyk-Bonikowska et al 2014, Młynarczyk-Bonikowska et al 2015.…”

Section: Introductionmentioning

confidence: 99%

Penicillinase Plasmid Australia type in Neisseria Gonorrhoeae Isolated in Poland

Walthoffen

2021

Preprint

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Purpose. Neisseria gonorrhoeae is an etiological agent of gonorrhea, which continues to be one of the most important public health problems. Currently, the most important problem in treatment is the mechanisms that determine resistance to drugs of the beta-lactam class, which are recommended for the treatment of gonorrhea. Chromosomal mutations are responsible for resistance to ceftriaxone and cefepime. The possibility of mutations in the gene encoding beta-lactamase (blaTEM) in the penicillinase plasmid may also turn out to be a serious threat. Methods. The occurrence of resistance encoded on penicillinase plasmid has been investigated. For this purpose, the susceptibility of bacteria was determined and the gene for resistance to beta-lactams as well as the plasmids themselves was typed. Results. Of the 333 strains tested, 21 (6.3%) had the beta-lactamase gene and produced penicillinase.The results allow to conclude that among the tested strains of N. gonorrhoeae occurred two of the beta-lactamase: TEM-1 and TEM-135. Most of the known penicillinase plasmid types of N. gonorrhoeae were demonstrated: Asian, African, Toronto/Rio plasmids and Australian variant.Conclusions.In the first three years, TEM-1 beta-lactamases dominated in N. gonorrhoeae, which were replaced by TEM-135 in the following years of the study. Not all molecular methods are capable of varying the types of penicillinase plasmids. A particularly noteworthy observation is the fact that the Australia-type of penicillinase plasmid (3270 bp) was identified for the first time in Europe, and the second time in the world.

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Problems of infection with <i>Neisseria gonorrhoeae</i>

Cited by 2 publications

References 20 publications

Penicillinase plasmid Australia type in Neisseria gonorrhoeae isolated in Poland

Penicillinase plasmid Australia type in Neisseria gonorrhoeae isolated in Poland

Penicillinase Plasmid Australia type in Neisseria Gonorrhoeae Isolated in Poland

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