Socially significant diseases are in the focus of world health care, because they affect a significant proportion of the able-bodied population and are the main causes of disability and death. The aim of the study was to carry out statistical analysis of the dynamics of morbidity of some socially significant diseases of the population of the Saratov region and comparative analysis of these data with similar indicators in the Russian Federation. Materials and methods. The statistical data published on the official site of the Federal State Statistics Service and the Russian Research Institute of Health of the Ministry of Health of Russia for the period from 2011 to 2021 were used. We built variation series and assessed the reliability of differences in relative indicators using Student’s t-criterion (p < 0.05 and t > 2). Results. Negative trends in the dynamics of primary and general morbidity of diseases characterized by high blood pressure, type 1 and 2 diabetes mellitus, and malignant neoplasms were recorded both in the region and in the Russian Federation. Conclusion. The obtained data regulate the necessity to conduct an in-depth study of the availability and quality of medical care for patients with socially significant diseases, as well as to develop measures to improve the provision of medical care for them.