Problems of neuroblastoma screening for 6 month olds and results of second screening for 18 month olds

Hayashi, Yoshie; Ohi, Ryoji; Yaoita, Seiichi; Nakamura, Michio; Kikuchi, Yūko; Konno, Tasuke; Tsuchiya, Shigeru; Shiraishi, Hiroyuki

doi:10.1016/0022-3468(95)90057-8

Cited by 23 publications

(9 citation statements)

References 5 publications

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“…Low-cost methods are necessary to satisfy the rising demand for mass screening in childhood (26)(27)(28)(29)(30). In view of its analytical characteristics, our technique could represent a new solution to these requests.…”

Section: Discussionmentioning

confidence: 99%

Determination of Vanillylmandelic, 5-Hydroxyindoleacetic and Homovanillic Acid in Urine by Isocratic Liquid Chromatography

Bonfigli¹,

Coppa²,

Testa³

et al. 1997

CCLM

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Summary:A new isocratic HPLC method, employing electrochemical detection, is described for the determination of urinary vanillylmandelic acid, 5-hydroxyindoleacetic acid and homovanillic acid. The main advantages of this technique are: simplicity, simultaneous determination of all analytes, the absence of an extraction procedure, isocratic elution and low cost. The diluted urine is injected onto a CIS reversed phase column. The mobile phase is potassium dihydrogenphosphate buffer containing 1-heptanesulphonic acid, methanol and acetonitrile. The calibration curves are linear from 0.1 to 50 mg/1; the precision data show CV less than 2.36% for within-day assay and less than 2.72% for day-to-day assays. The mean recoveries for supplemented samples are 98.2 to 102.0% for vanillylmandelic acid, 99.6 to 103.9% for 5-hydroxyindoleacetic acid and 98.7 to 102.0% for homovanillic acid. In comparisons of the present method with Radjaipur's extraction method (Radjaipur M. et al., Eur J Clin Chem Clin Biochem 1994; 32:609-13) the slopes for the three analytes were nearly 1, and the confidence region of the intercepts was close to 0. In conclusion the technique seems to be suitable for routine determination of the three analytes, especially for mass screening purposes.

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Section: Discussionmentioning

confidence: 99%

Determination of Vanillylmandelic, 5-Hydroxyindoleacetic and Homovanillic Acid in Urine by Isocratic Liquid Chromatography

Bonfigli¹,

Coppa²,

Testa³

et al. 1997

CCLM

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“…Furthermore, the number of patients that can be detected at a later time gets progressively smaller, and the likelihood of detecting unfavorable tumors in the window between detectability by screening and clinically symptomatic is small. It will take pilot data from a later screen in Japan or Europe to address these important questions [15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Biological aspects of neuroblastomas identified by mass screening in quebec

Brodeur

Look

Shimada

et al. 2001

Med. Pediatr. Oncol.

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Background Neuroblastoma has several characteristics that suggest that preclinical diagnosis might improve outcome. Therefore, the Quebec Neuroblastoma Screening Project was undertaken from 1989 to 1994 to examine infants at 3 weeks and 6 months by measuring urinary catecholamine metabolites. Procedure Over the 5‐yr period, 45 tumors were detected by screening, 20 were identified clinically prior to the third week, and 64 were identified clinically at a later time. We analyzed available tumors for Shimada histopathology, tumor ploidy, MYCN copy number and serum ferritin. Results Of the tumors detected by screening, only 2 of 45 tested had unfavorable histology, 2 of 45 had diploid or tetraploid DNA content, 0 of 43 had MYCN amplification, and 4 of 44 had elevated serum ferritin. All of these patients are alive and well. The 20 patients detected prior to the 3‐week screen had similar biological characteristics. In contrast, of the patients detected clinically after 3 weeks of age, 19 of 51 testedhad unfavorable histology, 25 of 66 had diploid or tetraploid tumors, 12 of 56 had MYCN amplification, and 14 of 54 had elevated ferritin. Conclusions The difference between the screened and clinically detected cases was highly significant for each biological variable. Preliminary data on other biological variables, such as neurotrophin expression and allelic loss on 1p in these patients are consistent with the above findings. These data suggest that mass screening for neuroblastoma at or before 6 months of age detects almost exclusively tumors that have favorable biological characteristics, many of which might have regressed spontaneously. Thus, continued mass screening for neuroblastoma at 6 months is unlikely to accomplish its intended goal, and should probably be discontinued. Med. Pediatr. Oncol. 36:157–159 2001. © 2001 Wiley‐Liss, Inc.

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“…In 1985, mass screening commenced as a nationwide program throughout Japan and, in 1988, screening by quantitative measurement of VMA, HVA, and creatinine was recommended by the Ministry of Health and Welfare. Since then, more than 7 million children have been screened in Japan, and more than 650 cases of neuroblastoma have been detected [5,7,28,[30][31][32][33][34][35][36][37][38][39]. There are numerous reports on screening from the various prefectures and time periods in Japan focusing on different aspects, making it a challenge to interpret the nationwide experience.…”

Section: Japanese Studiesmentioning

confidence: 99%

“…Thus, in some areas, a second screening was started aiming to rescue the false-negative cases. Hayashi et al [31] reported 40 cases receiving the first screening in Miyagi Prefecture in May 1992; 20 cases were positive, while 18 cases were false negative. Only 5 of 18 falsenegative cases were alive without the disease.…”

Section: Screening Failuresmentioning

confidence: 99%