Centers for Disease Control and Prevention (CDC) warns the use of one-way valves or
vents in face masks for potential threat of spreading COVID-19 through expelled
respiratory droplets. Here, we have developed a nanoceutical cotton fabric duly
sensitized with non-toxic zinc oxide nanomaterial for potential use as a membrane filter
in the one-way valve for the ease of breathing without the threat of COVID-19 spreading.
A detailed computational study revealed that zinc oxide nanoflowers (ZnO NFs) with
almost two-dimensional petals trap SARS-CoV-2 spike proteins, responsible to attach to
ACE-2 receptors in human lung epithelial cells. The study also confirmed significant
denaturation of the spike proteins on the ZnO surface, revealing removal of the virus
upon efficient trapping. Following the computational study, we have synthesized ZnO NF
on a cotton matrix using a hydrothermal-assisted strategy. Electron-microscopic,
steady-state, and picosecond-resolved spectroscopic studies confirm attachment of ZnO NF
to the cotton (i.e., cellulose) matrix at the atomic level to develop the nanoceutical
fabric. A detailed antimicrobial assay using
Pseudomonas aeruginosa
bacteria (model SARS-CoV-2 mimic) reveals excellent antimicrobial efficiency of the
developed nanoceutical fabric. To our understanding, the nanoceutical fabric used in the
one-way valve of a face mask would be the choice to assure breathing comfort along with
source control of COVID-19 infection. The developed nanosensitized cloth can also be
used as an antibacterial/anti CoV-2 washable dress material in general.