Problems with the Steinbrocker Staging System for Radiographic Assessment of the Rheumatoid Hand and Wrist

Kaye, Jeffrey; Fuchs, Hans; Jw, Moseley; Ep, Nance; Callahan, Leigh F.; Pincus, T

doi:10.1097/00004424-199005000-00011

Cited by 17 publications

(5 citation statements)

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“…The patients were classified into 4 groups based on radiographic stages of severity, according to the Steinbrocker criteria (32). Since the 4‐stage classification may be ambiguous (33, 34) but the difference between stage I and stages II–IV is distinct (i.e., the absence and presence, respectively, of destructive changes), for the purposes of this study the 4 groups were collapsed into 2, nonerosive RA (Steinbrocker stage I) and erosive RA (Steinbrocker stages II–IV). Blood samples were obtained from all subjects, and genomic DNA and serum were collected using standard protocols and stored at −70°C until use.…”

Section: Methodsmentioning

confidence: 99%

Association of Anti–Cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis

Cha¹,

Choi²,

Han³

et al. 2007

Arthritis & Rheumatism

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Objective. Anti-cyclic citrullinated peptide (anti-CCP) antibodies are rheumatoid arthritis (RA)-specific serologic markers. RA susceptibility has been associated with HLA-DRB1 shared epitope (SE) alleles and single-nucleotide polymorphism (SNP) haplotypes in the peptidyl arginine deiminase 4 gene (PADI4). This study was undertaken to determine whether anti-CCP levels are associated with PADI4 haplotypes and/or SE alleles in Korean patients with RA.Methods. Three nonsynonymous SNPs in PADI4 (padi4_89, padi4_90, and padi4_92) and SE alleles were genotyped, and serum anti-CCP levels were measured, in 311 patients with nonerosive or erosive RA. The relationships between anti-CCP levels and PADI4 haplotypes and/or SE alleles were analyzed statistically.

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Section: Methodsmentioning

confidence: 99%

Association of Anti–Cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis

Cha¹,

Choi²,

Han³

et al. 2007

Arthritis & Rheumatism

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“…Cross-sectional data from the baseline evaluation of these patients have been presented in previous reports concerning the joint count (50,51); radiographs (34,35,50,52,53); rheumatoid factor (35); grip strength, walk time, and button time (47); and self-report questionnaire data concerning ADL difficulty (36), pain (49), and helplessness (39,40). These reports include further details concerning methods used for data collection and data management.…”

Section: Patient Assessment At Baseline and 5-year Reviewmentioning

confidence: 99%

Measures of activity and damage in rheumatoid arthritis: Depiction of changes and prediction of mortality over five years

Callahan

Pincus

Huston

et al. 1997

Arthritis & Rheumatism

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128

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“…However, no radiographic assessment method has been achieved universal acceptance. In spite of the so-called Steinbrocker's method is not sensitive to clinically meaningful differences, is still widely used in clinical practise (32,35,36) including our Rheumatology Outpatient Department.…”

Section: Discussionmentioning

confidence: 99%

Antibodies against M. Bovis 65 KDa Heat Shock Protein and Its P180-188 Epitope in Sera of Patients with Juvenile Idiopathic Arthritis

Zlacka,

Hromadnikova,

Velek

et al. 2007

Int. J Biomed Sci.

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We screened the levels of antibodies to M. bovis hsp65 and the 180-188 epitope by using ELISA in a cohort of 72 juvenile idiopathic arthritis (JIA) patients and 38 healthy controls. We analysed an association between antibody levels and rheumatoid factor, antinuclear antibodies, human leukocyte antigen B27 and the severity and the duration of the disease. The majority of anti-hsp65 antibodies in a cohort of JIA patients were of the IgG isotype (54.2 %) with IgM (13.9%) antibodies increased to a lesser degree. IgG antibodies to M. bovis hsp65 (P<0.001) and the 180-188 epitope (P<0.001) were significantly increased in all of three disease onset types when compared with healthy controls. The highest levels of IgG antibodies to M. bovis hsp65 and its P180-188 epitope were observed in oligoarthritis and in patients with no X-ray changes and functional limitation, while the lowest antibody levels were detected in patients with the most severe stage of articular damage. When antibody levels to M. bovis hsp65 and the 180-188 epitope were examined within patient and control populations, significantly higher levels of IgG and IgM antibodies to M. bovis hsp65 were observed in both JIA (P<0.001) and healthy control (P<0.001) cohorts. These findings may suggest that the high levels of IgG antibodies to M. bovis hsp65 and its P180-188 epitope would reflect the least serious cases of JIA. Since IgM antibodies to M. bovis hsp65 and P180-188 M. bovis hsp65 epitope exceeded the control level in a few patients with JIA we believe they are not of concern.

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Problems with the Steinbrocker Staging System for Radiographic Assessment of the Rheumatoid Hand and Wrist

Cited by 17 publications

References 0 publications

Association of Anti–Cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis

Association of Anti–Cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis

Measures of activity and damage in rheumatoid arthritis: Depiction of changes and prediction of mortality over five years

Antibodies against M. Bovis 65 KDa Heat Shock Protein and Its P180-188 Epitope in Sera of Patients with Juvenile Idiopathic Arthritis

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