Procalcitonin and C-Reactive Protein in Hospitalized Adult Patients With Community-Acquired Pneumonia or Exacerbation of Asthma or COPD

Bafadhel, Mona; Clark, Tristan; Reid, C; Medina, Marie-Jo; Batham, Sally; Barer, Michael R.; Nicholson, Karl G.; Brightling, Christopher E.

doi:10.1378/chest.10-1747

Cited by 155 publications

(109 citation statements)

References 38 publications

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“…Simon et al 22 claimed procalcitonin is more accurate than CRP as a diagnostic indicator of bacterial infection. Bafadhel et al 23 asserted CRP is more effective than procalcitonin in term of AUC in assessing community-acquired pneumonia. Serum CRP has been found to rise in patients with chronic inflammatory diseases, including cardiovascular disease, metabolic syndrome and colorectal cancer 24 .…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Plasma Procalcitonin to Predict Severity in Elderly Patients With Community-Acquired Pneumonia

Kim

Mok

Jeon

et al. 2012

Chest

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Background: Community-acquired pneumonia (CAP) is one of the leading causes of death among the elderly. Several studies have reported the clinical usefulness of serum procalcitonin, a biomarker of bacterial infection. However, the association between the levels of procalcitonin and the severity in the elderly with CAP has not yet been reported. The aim of this study was to evaluate usefulness of procalcitonin as a predictor of severity and mortality in the elderly with CAP. Methods: This study covers 155 CAP cases admitted to Pusan National University Hospital between January 2010 and December 2010. Patients were divided into two groups (≥65 years, n=99; ＜65 years, n=56) and were measured for procalcitonin, C-reactive protein (CRP), white blood cell, confusion, uremia, respiratory rate, blood pressure, 65 years or older (CURB-65) and pneumonia severity of index (PSI). Results: The levels of procalcitonin were significantly correlated with the CURB-65, PSI in totals. Especially stronger correlation was observed between the levels of procalcitonin and CURB-65 in the elderly (procalcitonin and CURB-65, ρ=0.408 with p＜0.001; procalcitonin and PSI, ρ=0.293 with p=0.003; procalcitonin and mortality, ρ =0.229 with p=0.023). The correlation between the levels of CRP or WBC and CAP severity was low. The existing cut-off value of procalcitonin was correlated with mortality rate, however, it was not correlated with mortality within the elderly. Conclusion: The levels of procalcitonin are more useful than the levels of CRP or WBC to predict the severity of CAP. However, there was no association between the levels of procalcitonin and mortality in the elderly.

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Section: Discussionmentioning

confidence: 99%

Usefulness of Plasma Procalcitonin to Predict Severity in Elderly Patients With Community-Acquired Pneumonia

Kim

Mok

Jeon

et al. 2012

Chest

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“…It has been estimated that approximately 40%-50% of AECOPD cases are due to bacterial infections [32]. The precise contribution of bacterial infection is difficult to define because the airways of COPD patients may be chronically colonized [33,34].…”

Section: Discussionmentioning

confidence: 99%

Measurement of Procalcitonin in acute exacerbation of COPD and its correlation to SpirometricIndices

Bhaskar¹,

Singh²,

Singh³

et al. 2018

IJRDPL

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Available online on:15.01.2018@http://ijrdpl.co m http://dx.doi.org/10.21276/ IJRDPL.227 8-0238.2017.6(6).2906-2912 ABSTRACT:Background: rational prescription of antibiotics in acute exacerbation of COPD (AECOPD) requires predictive markers. Acute phase reactants are capable of demonstrating the inflammation; however, they cannot be employed to make a difference between bacterial and non-bacterial causes of the inflammation. The bacterial infection plays an important role in the exacerbation of COPD patients. Recently, measurement of serum procalcitonin levels appears to be useful in order to minimize this problem. We aim to evaluate the prognostic and diagnostic. Methods & methods: 51 COPD patients with bacterial exacerbations, 47 patients without bacterial exacerbations, similar age and sex were included in the study. PCT levels in the serum samples were measured in all subjects. Results: Procalcitonin levels ranged from 0.01 to 12.03 ng/ml. Mean levels were 3.18±2.60 ng/ml in Group I and 0.23±0.39 ng/ml in Group II. Median values in Groups I and II were 2.98 and 0.09 ng/ml respectively. Statistically, there was a significant difference between two groups (p<0.001) with Group I showing a higher mean value as compared to Group II. A significant near strong correlation was observed between TLC levels and serum Proclacitonin levels (r=0.699; p<0.001). However, a weak negative and borderline significant correlation. Conclusions: This study found increased PCT serum levels among AECOPD patients and suggests a role for PCT in the predicting of the bacterial exacerbations and their needs for ventilator support. We recommend other large studies to au gment our findings.

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“…Так в одном из исследований было показано, что чувствительным пороговым значением СРБ, разделившим больных ВП и пациентов с обостре-нием ХОБЛ, является 33 мг/л (чувствительность 83%, специфичность 44%) [16]. В другой публикации отмече-но, что у больных с обострением ХОБЛ, бронхиальной астмой значение СРБ > 48 мг/л обладало чувствительно-стью 91% (95% ДИ, 80-97%) и специфичностью -93% (95% ДИ, 86-98%) для выявления больных с пневмони-ей [17]. В отечественном исследовании показано, что при диагностике ВП у больных ХОБЛ пороговое значе-ние СРБ составляет ≥ 51,5 мг/л [18].…”

Section: хобл легкого и среднетяжелого течения без факторов рискаunclassified

Therapy for Exacerbations of Chronic Obstructive Pulmonary Disease

Зайцев¹

2017

Med. sov.

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В публикации рассматриваются вопросы современной фармакотерапии обострений хронической обструктивной болезни легких. Представлены критерии обострения, объем рекомендуемых исследований, показания к госпитализации, подходы к лечению, подробно рассмотрены режимы антимикробной терапии с учетом вероятных возбудителей обострения в зави-симости от тяжести течения ХОБЛ.Ключевые слова: обострение хронической обструктивной болезни легких, фармакотерапия, антимикробные препараты. А.А. ZAITSEV, MD, Burdenko General Military Clinical Hospital, Ministry of Defense of the RF THERAPY FOR EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASEThe article focuses on the current pharmacotherapy for exacerbations of chronic obstructive pulmonary disease. The author describes the exacerbation criteria, the amount of recommended examinations, indications for hospitalization, treatment approaches; antimicrobial therapy regimens determined by the type of the potential pathogen and depending on the severity of COPD are highlighted.

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Procalcitonin and C-Reactive Protein in Hospitalized Adult Patients With Community-Acquired Pneumonia or Exacerbation of Asthma or COPD

Cited by 155 publications

References 38 publications

Usefulness of Plasma Procalcitonin to Predict Severity in Elderly Patients With Community-Acquired Pneumonia

Usefulness of Plasma Procalcitonin to Predict Severity in Elderly Patients With Community-Acquired Pneumonia

Measurement of Procalcitonin in acute exacerbation of COPD and its correlation to SpirometricIndices

Therapy for Exacerbations of Chronic Obstructive Pulmonary Disease

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