Procalcitonin and C-reactive protein levels as diagnostic tools in febrile patients admitted to a General Internal Medicine ward

Ruiz-Esteban, Raul; Sarabia, Pilar Relea; Delgado, Emilio; Barros, Carlos; Cuervo-Arango, Jose Amerigo; Varela, Manuel

doi:10.1016/j.clinbiochem.2011.09.024

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…As a possible explanation they mentioned etiological heterogeneity of “febrile conditions” and clinical variations of “bacterial infections” which included severe bacteremia with high PCT, as well as localized infections with normal values of PCT. However, in subgroup analysis, significantly higher PCT values were in the group of patients with infectious diseases (PCT 1.012 ng / ml, 95% CI, 0.342 to 1.683), compared to an immune inflammatory conditions (PCT 0.187 ng / ml, 95% CI , 0-0.427), and in subjects with bacterial, compared to the viral febrile illness (double Welch t-test t = 2.76, DF = 37.423, p = 0.009) (18). …”

Section: Diagnostic Importance Of Procalcitoninmentioning

confidence: 99%

The Importance of Serum Procalcitonin in Diagnosis and Treatment of Serious Bacterial Infections and Sepsis

Mehanic

Baljić

2013

Mater Sociomed

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The clinical utility of serum procalcitonin (PCT) levels continues to evolve. PCT is regarded as a promising candidate marker for making a diagnosis and antibiotic stewardship in patients with systemic infections. The aim of this review is to summarize the current evidence for PCT in different infections and clinical settings, and to discuss the reliability of this marker when used with validated diagnostic algorithms.

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Section: Diagnostic Importance Of Procalcitoninmentioning

confidence: 99%

The Importance of Serum Procalcitonin in Diagnosis and Treatment of Serious Bacterial Infections and Sepsis

Mehanic

Baljić

2013

Mater Sociomed

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“…In the clinical practice of GIM, infections are the most common diagnoses, and relevant research and guidelines on PCT application are much needed. However, there were very few relevant or targeted studies (17). Our in-depth analysis of the literature showed that most research in this area was on the application of PCT in critically ill patients.…”

Section: Discussionmentioning

confidence: 99%

Procalcitonin in general internal medicine: a bibliometric analysis

Zhang¹,

Zhao²,

Zhao³

et al. 2021

Ann Palliat Med

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Background: Procalcitonin (PCT) plays an important role in the identification of bacterial infection and therapy guidance. The relevant literature is mainly classified under critical care medicine or infectious disease. The research status of PCT in general internal medicine (GIM) is currently unclear. This research aimed to analyze PCT-related literature in the GIM field and provide references for future research.Methods: A subject search strategy was used for the term PCT, with the search scope limited to Medicine, General & Internal. We conducted a search of relevant literature in the Science Citation Index Expanded (SCIE) database in the Web of Science Core Collection (WOSCC), with no publication date limit (1900 to May 16, 2021, the date of the final search for this study). The search results were analyzed using CiteSpace software to assess the status of PCT research in the GIM field based on annual paper publication numbers, the number of citations, country distribution, institution distribution, author distribution, journal distribution, and keyword usage.Results: A total of 905 document records were retrieved. Articles were mainly from Europe, the United States, and China, and the number of citations totaled 15,917. There were 5 research institutions that published more than 10 related papers and 3 authors who published more than 10 papers. There was little cooperation between authors from different countries and institutions. This field should focus on leading journals in critical care medicine and quality comprehensive journals. Keyword analysis showed that the current research focus is the standardized application of PCT.Conclusions: There are few targeted studies on the application of PCT in GIM, and the relevant important literature mainly comes from other journals. GIM-specific research should be increased in the future.

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“…(Stolz et al, 2006) Although the sponsor cites this study that identified strong performance for the diagnostic accuracy of PCT, there are multiple peerreviewed published studies that suggest that PCT has limited ability to discriminate between bacterial and viral infections. (Chan et al, 2004;Holm et al, 2007;Indino et al, 2008;Ip et al, 2007;Kherad et al, 2010;Ruiz-Esteban et al, 2012;Steichen et al, 2009). Previously published literature has provided a range of sensitivities from 0.31 -0.94 and specificities from 0.71 -0.98.…”

Section: A Lrtimentioning

confidence: 99%

“…Meta-analyses may be subject to publication bias, the tendency of published studies in a research area to be unrepresentative of all of the completed studies in that area. (Rothstein HR, 2005;Song, Eastwood, Gilbody, Duley, & Sutton, 2000). Funnel plots and statistical tests are available for evaluating a meta-analysis for publication bias.…”

Section: Statistical Considerationsmentioning

confidence: 99%

Updated concepts in the diagnosis and management of community-acquired pneumonia

Hunton

2019

Jaapa

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Pneumonia accounts for about 1 million hospitalizations each year in the United States. It is the number one cause of death from infectious disease and eighth leading cause of death in the United States. This article reviews recent updates in best practices for diagnosing and managing pneumonia in the ED or primary care practice. Despite developments in the diagnosis of pneumonia, vital signs and chest examination findings can and should guide clinical management. Chest radiography is routinely used to diagnose pneumonia. However, a negative chest radiograph should not replace clinical impression. In immunocompetent patients with community-acquired pneumonia, the CURB-65 decision rule has a role in identifying high-risk patients, including those who will require ICU admission and a critical care intervention.

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Procalcitonin and C-reactive protein levels as diagnostic tools in febrile patients admitted to a General Internal Medicine ward

Cited by 7 publications

References 36 publications

The Importance of Serum Procalcitonin in Diagnosis and Treatment of Serious Bacterial Infections and Sepsis

The Importance of Serum Procalcitonin in Diagnosis and Treatment of Serious Bacterial Infections and Sepsis

Procalcitonin in general internal medicine: a bibliometric analysis

Updated concepts in the diagnosis and management of community-acquired pneumonia

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