Procalcitonin and severity of community-acquired pneumonia

Usefulness of a semi‐quantitative procalcitonin test and the A‐DROP Japanese prognostic scale for predicting mortality among adults hospitalized with community‐acquired pneumonia

“…The A‐DROP scale differs from the CURB‐65 scale with respect to the following points: (i) the possibility of replacing blood urea nitrogen levels with clinical findings of intra‐oral and skin dryness; and (ii) adjustment of the age parameter for differences in life expectancy between the genders. Similar to the findings documented previously regarding the simultaneous use of PCT levels and either CURB‐65 or PSI scores, 19,22 the present results also support the value of PCT levels when used in combination with A‐DROP scores. The present study also showed that the semi‐quantitative PCT test was useful and facilitated the prediction of patient outcomes at their first outpatient consultation 19,21,23–25 …”

Guidelines for the management of adult lower respiratory tract infections - Full version

“…[263]Biomarkers improve mortality prediction by prognostic scales in community‐acquired pneumoniaPCS3A+ Okimoto et al. [265]Procalcitonin and severity of community‐acquired pneumoniaRCS4C− Kruger et al. [266]Pro‐atrial natriuretic peptide and pro‐vasopressin to predict severity and prognosis in community‐acquired pneumonia: results from the German competence network CAPNETZPCS3A+ Kruger et al.…”

“…Biomarkers (C-reactive protein (CRP)) [228,[261][262][263][264], procalcitonin (PCT) [228,263,265,266], D-dimer [267], carboxy-terminal provasopressin (CT-proAVO, copeptin) [268], midregional proatrial natriuretic peptide (MR-pro-ANP) [266,269,270], midregional proadrenomedullin (MR-ADM) [271,272], and triggering receptor expressed on myeloid cells (TREM-1) [273], as well as the adrenal response [274,275], as an alternative or additional tool for the assessment of pneumonia severity, have recently gained much attention. It appears that all of them seem to have a significant potential to predict mortality.…”

Guidelines for the management of adult lower respiratory tract infections - Summary

“…CRP or procalcitonin) have a significant potential to improve severity assessment but have not been sufficiently evaluated for the decision to hospitalize. [A3] [141,145,161–191].…”