Procalcitonin as a diagnostic marker and IL-6 as a prognostic marker for sepsis

Jekarl, Dong Wook; Lee, So‐Young; Lee, Jehoon; Park, Yeon-Joon; Kim, Yonggoo; Park, Jeong Ho; Wee, Jung Hee; Choi, Seung Pill

doi:10.1016/j.diagmicrobio.2012.12.011

Cited by 153 publications

(154 citation statements)

References 24 publications

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“…This finding is not consistent with research by Suarez-Santamaria et al (2010), who found that the IL-10 and IL-6 expression levels were the best predictors of survival in sepsis. Similarly, Jekarl et al (2013) found significantly increased IL-6 levels in nonsurvivors compared to survivors. Our antibody array results also showed a large variation in IL-6 levels between the two groups.…”

Section: Discussionmentioning

confidence: 80%

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Zhu

Liao

Feng

et al. 2017

Tohoku J. Exp. Med.

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Sepsis is a systemic host response to infection, and patients with sepsis are frequently handled in the intensive care unit. However, mortality related to sepsis remains high throughout the world. In addition, there have been no efficient prognostic biomarkers for sepsis to be employed in clinical practice. We therefore aimed to identify prognostic biomarkers for sepsis using the chemokine/cytokine array. This study included 143 patients with sepsis, who were divided into survivor and nonsurvivor groups according to their 28-day mortality status. The cytokine array analysis was performed with plasma samples from two randomly selected patients in each sepsiofgroup. We thus identified seven cytokines with significantly and consistently different expression levels between nonsurvivors and survivors. The validity of the selected cytokines was then assessed by enzyme-linked immunosorbent assay (ELISA). We finally found monocyte chemoattractant protein 1 (MCP-1) as the most useful biomarker to distinguish the two sepsis groups; namely, non-surviving patients (n = 56) exhibited significantly higher plasma concentrations of MCP-1 compared to survivors (n = 87). MCP-1 is a CC chemokine, a potent chemoattractant that contributes to systemic inflammatory response syndrome. Areas under the receiver operating characteristic curves for prediction of 28-day mortality were 0.763 for MCP-1, 0.680 for the Acute Physiologic Assessment and Chronic Health Evaluation II (APACHE II) score, 0.64 for the Sequential Organ Failure Assessment (SOFA) score, 0.621 for procalcitonin, and 0.785 for MCP-1 plus APACHE II score. In conclusion, we propose that plasma MCP-1 is a useful biomarker in predicting outcome of sepsis.

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Section: Discussionmentioning

confidence: 80%

Plasma Monocyte Chemoattractant Protein 1 as a Predictive Marker for Sepsis Prognosis: A Prospective Cohort Study

Zhu

Liao

Feng

et al. 2017

Tohoku J. Exp. Med.

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“…IL-6 was significant independent predictors of severe sepsis [6]. And, the previous study showed that IL-6 was useful marker for prognosis of sepsis [7]. Thus, IL-6 was remarkable cytokine for sepsis.…”

Section: Introductionmentioning

confidence: 84%

Effect of High-Dose Intravenous Immunoglobulin Administration on the Levels of Interleukin-6 in Patients with Sepsis

Kusunoki¹,

Nishi²,

Umegaki³

et al. 2017

Intensive & Crit Care

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“…A limitation to the value of IL-6 as a biomarker is the fact that an array of other diseases are also associated with in an increase in IL-6 levels ( [59]; e. g., autoimmune diseases, surgery, and trauma). In patients with severe sepsis or septic shock, a reduction in IL-6 levels can be used as a prognostic factor [66]. The kinetics of the IL-6 level can be used to monitor the effectiveness of an antiinfective therapy [66].…”

Section: Interleukinmentioning

confidence: 99%

“…In patients with severe sepsis or septic shock, a reduction in IL-6 levels can be used as a prognostic factor [66]. The kinetics of the IL-6 level can be used to monitor the effectiveness of an antiinfective therapy [66]. Despite these advantages and the increasing trend toward chemical laboratory measurement of IL-6 in emergency departments and ICUs, IL-6 is not a routine parameter for diagnosis of sepsis in adult patients.…”

Section: Interleukinmentioning

confidence: 99%