Procalcitonin as an early marker of infection in neonates and children

Rossum, Annemarie M. C. van; Rw, Wulkan; Oudesluys‐Murphy, Anne Marie

doi:10.1016/s1473-3099(04)01146-6

Cited by 267 publications

(169 citation statements)

References 83 publications

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“…The role of procalcitonin (PCT) as a biomarker for sepsis in adults is well documented, while its role in infections affecting neonatal children remains controversial [3]. Among these infections, Community-Acquired pneumonia (CAP) has been studied extensively, because it's the second cause of death in children in developing countries, and one of the most frequent causes of hospitalization in industrialized countries [4].…”

Section: Introductionmentioning

confidence: 99%

Procalcitonin and community-acquired pneumonia (CAP) in children

Bivona

Agnello

Scazzone

et al. 2015

Clinica Chimica Acta

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Section: Introductionmentioning

confidence: 99%

Procalcitonin and community-acquired pneumonia (CAP) in children

Bivona

Agnello

Scazzone

et al. 2015

Clinica Chimica Acta

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“…However, most studies investigating this early marker of neonatal EOS concluded that procalcitonin is not better than CRP in assessing EOS and that its diagnostic accuracy is complicated by a physiological increase during the first days of life. 4 Several studies, analyzing term infants suspected of sepsis, have recently shown that inflammatory markers such as whole-blood IL-8 and neutrophil CD64 are very sensitive indicators of EOS in a research setting, [5][6] yet because of special handling requirements, they are not readily available in hospital laboratories.…”

Section: Introductionmentioning

confidence: 99%

Serum amyloid A: an early and accurate marker of neonatal early-onset sepsis

et al. 2007

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Objectives: To evaluate the accuracy of serum amyloid A (SAA), an acute phase protein in the detection of neonatal early-onset sepsis, by means of a fast automated SAA kit.Study Design: Full-term infants <72 h of age, who had risk factors and/or were suspected of having sepsis, were eligible for study. The levels of SAA were taken at 0, 24 and 48 h post sepsis evaluation. Thirty matched infants served as a control group for comparing SAA concentrations.Results: Of 104 infants eligible for entry to the study, 23 had sepsis and 81 had not sepsis. The SAA levels of the septic group were significantly higher than those of the nonseptic group at 0, 24 and 48 h (P<0.01 for all time points). In comparison with C-reactive protein (CRP), SAA levels rose earlier and in a sharper manner, had higher levels and returned faster to normal values in infants with early onset sepsis. At 0 h post-sepsis evaluation, serum SAA had an overall better diagnostic accuracy for predicting early onset sepsis than CRP (sensitivity (96 vs 30%), specificity (95 vs 98%), positive predictive value (85 vs 78%), negative predictive value (99 vs 83%), positive likelihood ratio (19 vs 12), and negative likelihood ratio (0.05 vs 0.71).Conclusions: SSA is advocated as an inflammatory marker of neonatal early-onset sepsis.

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“….) and the results are variable [26][27][28][29][30][31][32][33][34][35][36]. Kuhn et al [28] found a sensitivity and specificity less important that in our study (Se: 76.5 versus 78.6%; Sp: 82.7 versus 96.2%) in case of nosocomial infection.…”

Section: Late-onset Neonatal Sepsis (Lons)mentioning

confidence: 67%