Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis-related cytokines in vitro

Oberhoffer, M.; Stonâns, Ilmars; Rußwurm, Stefan; Stonane, Elita; Vogelsang, Heinz; Junker, U.; Jäger, Lothar; Reinhart, Konrad

doi:10.1016/s0022-2143(99)90053-7

Cited by 297 publications

(224 citation statements)

References 23 publications

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“…PCT is an established marker produced to some extent by leucocytes [2] used for specific and rapid diagnosis of neutropenic sepsis which is a medical emergency demanding active medical intervention [7,8]. The prognostic significance of PCT has already been established in studies with immunocompetent adult patients in ICU [9,10] and in children with febrile neutropenia [11,12].…”

Section: Discussionmentioning

confidence: 99%

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PCT as a Prognostic Marker in Cardiac Patients with Neutropenic Sepsis: Two Case Reports

et al. 2013

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Procalcitonin (PCT) is an innovative and highly specific marker for diagnosis of clinically relevant bacterial infection and sepsis. PCT supports early diagnosis and Clinical decision making. A retrospective study of two classical cases of neutropenic sepsis with elevated PCT levels in cardiac ICU was done. PCT was analyzed using Elecsys Brahms PCT kit. Serum PCT levels \0.5 ng/ml and ANC\1,000/mm 3 was taken as cutoff. The first patient had initial high levels of PCT 100 ng/ml, TLC 13,600/mm 3 and ANC 12,250/mm 3 . It was followed by drop with subsequent rise in PCT levels and drop in TLC 1,000/mm 3 and ANC 70/mm 3 . The second patient had normal PCT 0.116 ng/ml, TLC 5,600/mm 3 and ANC 4,420/mm 3 levels followed with sharp increase in all the values with subsequent drop in TLC 2,000/mm 3 and ANC 880 cells/mm 3 . Both the patients died of neutropenic sepsis with multiorgan failure. The case reports showed the correlation of PCT with TLC and ANC levels in predicting the mortality of patients with neutropenic sepsis in cardiac ICU.

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Section: Discussionmentioning

confidence: 99%

“…Procalcitonin (PCT) is a polypeptide consisting of 116 amino acids, the precursor of calcitonin normally produced by C cells of thyroid gland [1] and secreted to some extent by leukocytes [2]. Serum PCT elevation was first reported in patients with bacterial sepsis [3].…”

Section: Introductionmentioning

confidence: 99%

PCT as a Prognostic Marker in Cardiac Patients with Neutropenic Sepsis: Two Case Reports

et al. 2013

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“…1, P It is known that OKT3 induces a massive release of tumor necrosis factor alpha (TNF-a) [l]. Oberhoffer et al [3] found a pronounced stimulatory effect of TNF-a on expression of PCT mRNA. However, the rise of PCT levels observed under rejection therapy with OKT3 is not directly OKT3-mediated, but due to the intermediate step of TNF-a release.…”

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confidence: 99%

Procalcitonin increase after anti-CD3 monoclonal antibody therapy does not indicate infectious disease

Kuse

Jaeger

2001

Transplant International

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“…Both PCT and IL‐6 are produced by a broad range of cells,22, 23 whereas CRP is largely produced in the liver 21. Interleukin‐6 induces production of both PCT and CRP 21, 24. These production sites and common pathways might affect correlations.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of interleukin‐6 may predict organ dysfunction earlier than SOFA score

Shimazui

Matsumura

Nakada

et al. 2017

Acute Medicine & Surgery

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AimTo investigate the clinical utility of interleukin‐6 (IL‐6), procalcitonin (PCT), and C‐reactive protein (CRP) as predictive markers in consideration of the time‐course changes in critically ill patients with organ dysfunction.MethodsSerum levels of IL‐6, PCT, CRP, and Sequential Organ Failure Assessment (SOFA) scores were measured sequentially in 92 patients during their initial 5 days following admission to the intensive care unit. Maximum values were analyzed. Patients were assigned to a low ( ≤ 8), intermediate ( > 8 and ≤ 16), or high ( > 16 and ≤ 24) SOFA score group.ResultsThere were significant differences in the maximum serum levels of IL‐6 and PCT among the three SOFA score groups (IL‐6, P < 0.0001; PCT, P = 0.0004). Specifically, comparisons between the groups revealed significant differences in IL‐6 levels (low versus intermediate, P = 0.0007; intermediate versus high, P = 0.0010). The probability of patients with the maximum value was greatest on day 1 (56.5%) for IL‐6, on day 1 (39.1%) or day 2 (38.0%) for PCT, on day 3 (39.1%) for CRP, and on day 1 (43.5%) for SOFA score. The median (interquartile range) peak day of IL‐6 was day 1 (1–2), which was significantly earlier than that of SOFA score at day 2 (1–3) (P = 0.018).ConclusionSerum levels of IL‐6 reflected the severity of organ dysfunction in critically ill patients most accurately compared to PCT and CRP. Interleukin‐6 elevated soonest from the insult and reached its peak earlier than SOFA score.

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Procalcitonin expression in human peripheral blood mononuclear cells and its modulation by lipopolysaccharides and sepsis-related cytokines in vitro

Cited by 297 publications

References 23 publications

PCT as a Prognostic Marker in Cardiac Patients with Neutropenic Sepsis: Two Case Reports

PCT as a Prognostic Marker in Cardiac Patients with Neutropenic Sepsis: Two Case Reports

Procalcitonin increase after anti-CD3 monoclonal antibody therapy does not indicate infectious disease

Serum levels of interleukin‐6 may predict organ dysfunction earlier than SOFA score

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