Procalcitonin for detecting community-acquired bacterial pneumonia

Gusmaiyanto, Devi; Yani, Finny Fitry; Efrida, Efrida; Machmud, Rizanda

doi:10.14238/pi55.2.2015.65-69

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…This result was similar to a study by Bekdas M, et al 16 8 . Another study showed that the 0.5 ng/ml procalcitonin cut-off point had a sensitivity of 93% and a specificity of 74% as a marker of infection 17 .…”

Section: Discussionmentioning

confidence: 99%

Agreement between neutrophil/lymphocyte ratio and procalcitonin for determining severe community acquired pneumonia in children

Aryani

Mayangsari

Gunawijaya

et al. 2022

Sri Lanka J Child Health

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Introduction:The use of inflammatory markers, such as procalcitonin, in assessing the severity of community acquired pneumonia (CAP) is limited by its relatively high cost. Currently, the Neutrophil/Lymphocyte ratio (NLR) is considered to have an important role in the inflammatory process.Objectives: To evaluate the agreement between NLR and procalcitonin for determining severe CAP in children. Method:This was a cross-sectional study carried out in children aged 2 months to 18 years with CAP in the paediatric unit at Sanglah Hospital, Denpasar, Bali, Indonesia from August 2019 -March 2021. Statistical analysis was performed using receiver operating characteristic (ROC) curve to find the cutoff point of NLR. Analysis was done to determine severe CAP based on cut-off points of procalcitonin and NLR. Cohen's Kappa analysis between NLR and procalcitonin was performed for determining severe CAP with significant p-value <0.05.Results: There were 58 subjects analysed in this study. Analysis performed by ROC showed cut off point of NLR was 2.11 with sensitivity of 82.4% and specificity of 83.3% while procalcitonin had a cutoff point of 1 ng/ml with a sensitivity 85.3% and specificity 87.5% to predict severe CAP. The agreement analysis between NLR with cut-off point 2.11 and procalcitonin with cut-off point 1 ng/ml showed substantial agreement for determining severe CAP in children (k=0,62; p=0,001).

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Section: Discussionmentioning

confidence: 99%