Procalcitonin in hypoxic brain damage

Lateef, Aisha; Khoo, See Meng; Lee, K. H.

doi:10.1007/s00134-004-2541-9

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Nonetheless, the serum levels are low compared with proCT levels used as a marker for sepsis (0.5 ng/mL to 6 ng/mL), 44 and level of over 4000 ng/mL reported in a patient following myocardial infarction. 45 Thus, while it seems reasonable that sufficient proCT can be generated in vivo to activate the CGRP receptor, whether these levels are reached during migraine remains speculative.…”

Section: Discussionmentioning

confidence: 99%

Reactive Oxygen Species Induce Procalcitonin Expression in Trigeminal Ganglia Glia

Raddant

Russo

2014

Headache

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Objective To examine calcitonin gene-related peptide (CGRP) gene expression under inflammatory conditions using trigeminal ganglia organ cultures as an experimental system. These cultures have increased proinflammatory signaling that may mimic neurogenic inflammation in the migraine state. Background The trigeminal nerve sends peripheral pain signals to the central nervous system during migraine. Understanding the dynamic processes that occur within the trigeminal nerve and ganglion may provide insights into events that contribute to migraine pain. A neuropeptide of particular interest is CGRP, which can be elevated and play a causal role in migraine. However, most studies have overlooked a second splice product of the CALCA gene, which encodes calcitonin (CT), a peptide hormone involved in calcium homeostasis. Importantly, a precursor form of calcitonin called procalcitonin (proCT) can act as a partial agonist at the CGRP receptor and elevated proCT has recently been reported during migraine. Methods We used a trigeminal ganglion whole organ explant model, which has previously been demonstrated to induce pro-inflammatory agents in vitro. Quantitative PCR and immunohistochemistry were used to evaluate changes in mRNA and protein levels of CGRP and proCT. Results Whole mouse trigeminal ganglia cultured for 24 h showed a 10-fold increase in CT mRNA, with no change in CGRP mRNA. A similar effect was observed in ganglia from adult rats. ProCT immunoreactivity was localized in glial cells. Cutting the tissue blunted the increase in CT, suggesting that induction required the close environment of the intact ganglia. Consistent with this prediction, there were increased reactive oxygen species in the ganglia and the elevated CT mRNA was reduced by antioxidant treatment. Surprisingly, reactive oxygen species were increased in neurons, not glia. Conclusions These results demonstrate that reactive oxygen species can activate proCT expression from the CGRP gene in trigeminal glia by a paracrine regulatory mechanism. We propose that this glial recruitment pathway may occur following cortical spreading depression and neurogenic inflammation to increase CGRP nociceptive actions in migraine.

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Section: Discussionmentioning

confidence: 99%

Reactive Oxygen Species Induce Procalcitonin Expression in Trigeminal Ganglia Glia

Raddant

Russo

2014

Headache

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“…8 Además, la elevación de la procalcitonina ha sido reportada en los procesos inflamatorios relacionados con trauma, cirugía, infarto de miocardio, falla cardíaca y en la encefalopatía isquémica posterior a infarto de miocardio. 16 En otros padecimientos con compromiso vascular, como la preeclampsia, se ha encontrado que los niveles de la procalcitonina, la PCR y del dímero D son mayores a los encontrados en el grupo control sano (p= 0,001). 17 Además, la procalcitonina, junto con la PCR, han sido utilizadas como marcadores que detectan de manera temprana la presencia de fístulas asociadas a la realización de una gastrectomía.…”

Section: La Procalcitonina En Los Procesos No Infecciososunclassified

Procalcitonina como biomarcador diagnóstico de sepsis en el niño con cáncer, neutropenia y fiebre: revisión de la literatura

Reyna-Figueroa¹,

Lagunas‐Martínez

Matsumoto

et al. 2015

Arch Argent Pediat

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“…Nonetheless, they are low compared to the levels of proCT used as a marker for sepsis (0.5 ng/ml to 6 ng/ml) [234], and a concentration over 4000 ng/ml has been reported in a patient following myocardial infarction [235]. Thus, while it seems reasonable that sufficient proCT can be generated in vivo to activate the CGRP receptor; however, whether these levels are reached during migraine remains speculative.…”

Section: Antioxidant Treatment Blunts Culture Induced Ct Expressionmentioning

confidence: 98%

Regulation of CGRP gene expression and effects on light aversive behavior

Raddant¹

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Procalcitonin in hypoxic brain damage

Cited by 6 publications

References 5 publications

Reactive Oxygen Species Induce Procalcitonin Expression in Trigeminal Ganglia Glia

Reactive Oxygen Species Induce Procalcitonin Expression in Trigeminal Ganglia Glia

Procalcitonina como biomarcador diagnóstico de sepsis en el niño con cáncer, neutropenia y fiebre: revisión de la literatura

Regulation of CGRP gene expression and effects on light aversive behavior

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