Procalcitonin is a prognosis biomarker in very preterm neonates with late onset sepsis: a pilot study

Ruetsch, Valerie; Barreault, Simon; Saché, Nolwenn Le; Tissères, Pierre

doi:10.1007/s00431-021-04326-2

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…However, other studies have shown that serum amyloid A, the expression of CD64 on neutrophils surface, presepsin and endocan have higher potential for a more accurate diagnosis of LOS [ 210 , 211 , 214 ]. Procalcitonin (PCT), another acute phase reactant, holds promising sensitivity for the prediction of LOS alone [ 215 , 216 ] and in combination with IL-6 [ 212 ]. Sherbiny and collaborators have also shown that hepcidin, which controls the levels of systemic iron [ 217 ], constitutes another possibility for rapid and accurate diagnostics of LOS [ 218 , 219 ].…”

Section: Los Diagnosis and Treatmentmentioning

confidence: 99%

The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies

França

2023

Antibiotics

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Infections are one of the most significant complications of neonates, especially those born preterm, with sepsis as one of the principal causes of mortality. Coagulase-negative staphylococci (CoNS), a group of staphylococcal species that naturally inhabit healthy human skin and mucosa, are the most common cause of late-onset sepsis, especially in preterms. One of the risk factors for the development of CoNS infections is the presence of implanted biomedical devices, which are frequently used for medications and/or nutrient delivery, as they serve as a scaffold for biofilm formation. The major concerns related to CoNS infections have to do with the increasing resistance to multiple antibiotics observed among this bacterial group and biofilm cells’ increased tolerance to antibiotics. As such, the treatment of CoNS biofilm-associated infections with antibiotics is increasingly challenging and considering that antibiotics remain the primary form of treatment, this issue will likely persist in upcoming years. For that reason, the development of innovative and efficient therapeutic measures is of utmost importance. This narrative review assesses the current challenges and emerging diagnostic tools and therapies for the treatment of CoNS biofilm-associated infections, with a special focus on late-onset sepsis.

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Section: Los Diagnosis and Treatmentmentioning

confidence: 99%

The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies

França

2023

Antibiotics

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“…У новорожденных высокое значение PCT считается биомаркером неонатального сепсиса с поздним началом. У недоношенных детей с поздним неонатальным сепсисом PCT имеет прогностическое значение [29]. Показатель PCT является чувствительным биомаркером для выявления послеоперационного сепсиса у детей [30] и у групп риска по заболеваемости и смертности от сепсиса [31].…”

Section: Pctunclassified

Биологические Маркеры Сепсиса

Радыгина,

Мочалова

2023

Microbiology Independent Research Journal (MIR Journal)

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В настоящее время проблема ранней диагностики сепсиса, оценки эффективности проводимой терапии и прогноза течения заболевания крайне актуальна. При сепсисе своевременное оказание медицинской помощи осложнено нечеткостью симптомов и отсутствием специфического диагностического теста. В связи с этим во всем мире ведется поиск биологических маркеров сепсиса: диагностических, прогностических и терапевтических. В обзоре суммированы результаты исследований по диагностической ценности биологических маркеров сепсиса, их чувствительности, специфичности и прогностической ценности из научных публикаций, представленных в международных базах данных.

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“…In newborns, elevated PCT is considered a biomarker for late-onset neonatal sepsis. Regarding preterm infants with late neonatal sepsis, PCT has a prognostic significance [29]. PCT is a sensitive biomarker detecting postoperative sepsis in children [30] as well as in risk groups for sepsis morbidity and mortality [31].…”

Section: Procalcitonin (Pct)mentioning

confidence: 99%

Biological markers of sepsis

Radygina,

Mochalova

2023

Microbiology Independent Research Journal (MIR Journal)

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Currently, the issues of early sepsis diagnosis, assessment of the effectiveness of therapies conducted, and disease prognosis are extremely relevant. In the case of sepsis, timely medical assistance is complicated by the ambiguity of symptoms and the absence of a specific diagnostic test. Therefore, the search for sepsis biomarkers with diagnostic, prognostic, and therapeutic potential is underway in medical centers worldwide. This review summarizes research results regarding the diagnostic values of sepsis biomarkers – their sensitivity, specificity, and prognostic value – as presented in scientific publications indexed in international databases.

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Procalcitonin is a prognosis biomarker in very preterm neonates with late onset sepsis: a pilot study

Cited by 5 publications

References 25 publications

The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies

The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies

Биологические Маркеры Сепсиса

Biological markers of sepsis

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