Procalcitonin is useful whereas C-reactive protein is not, to predict                 complications following coronary artery bypass surgery

Macrina, Francesco; Tritapepe, Luigi; Pompei, F.; Sciangula, Alfonso; Evangelista, Ernesto; Toscano, F.; Criniti, Anna; Brancaccio, Gianluca; Puddu, Paolo Emilio

doi:10.1191/0267659105pf800oa

Cited by 20 publications

(20 citation statements)

References 23 publications

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“…Several trials have proved the poor diagnostic value of CRP in the postoperative period especially if compared with PCT. Macrina et al [2] used CrP to follow septic patients and found that CrP was unable to predict the outcome of disease or severity.…”

Section: Discussionmentioning

confidence: 99%

“…After surgery C-reactive protein (CrP) is widely used to monitor the postoperative course, especially with regard to infection. However, several trials showed a lower sensitivity in the (early) postoperative period for CrP in comparison to procalcitonin (PCT) that has become increasingly popular as a marker of infection after surgical procedures [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of procalcitonin and CrP in the postoperative course after lung decortication

Carboni

Fahrner

Gazdhar

et al. 2008

European Journal of Cardio-Thoracic Surgery

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Objective: The objective of this prospective study was to compare the clinical value of procalcitonin (PCT) and C-reactive protein (CrP) plasma concentrations in their postoperative course after decortication. Methods: Twenty-two patients requiring surgery for pleural empyema were chosen for this prospective study. Routine blood samples including CrP and PCT plasma concentrations were taken before the operation and on the 1st, 2nd, 3rd, and 7th postoperative day. Results: Due to infection PCT and CrP were elevated preoperatively. In the postoperative course both PCT and CrP reached peak-levels on day 2 with values up to 43.55 ng/ml and 384.00 mg/l, respectively. In PCT the rise was followed by a clear decrease in 20 (90.9 %) patients until day 7. In contrast the CrP levels decreased slowly and only seven (54.5%) patients had values of 100 mg/l or below on day 7. PCT showed a better correlation with the clinic in case of septic course than CrP does. Conclusions: PCT reflects postoperative clinical course more accurately than CrP. Therefore, PCT is a more appropriate laboratory parameter to monitor patients after surgery for pleural empyema. #

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of procalcitonin and CrP in the postoperative course after lung decortication

Carboni

Fahrner

Gazdhar

et al. 2008

European Journal of Cardio-Thoracic Surgery

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“…C-reactive protein (CRP) levels increase postoperatively, peaking between postoperative days one and three and remaining elevated up to the second week postoperatively [29,30,35,54]. irrespective of the extent of surgery [33,34,36,38,42,45,46,54]. Levels of interleukin-6 (IL-6), another marker of immune system activation, also increase postoperatively [34,41,46,48,50,55,56].…”

Section: Methodsmentioning

confidence: 99%

“…Several studies reported higher PCT levels after cardiac surgery in infected compared with non-infected patients [33,35-38,41,45,57,58]. Importantly, PCT levels remained elevated in the first week postoperatively [35,37,38].…”

Section: Methodsmentioning

confidence: 99%

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Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature

et al. 2006

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Introduction Systemic inflammatory response syndrome is common after surgery, and it can be difficult to discriminate between infection and inflammation. We performed a review of the literature with the aims of describing the evolution of serum procalcitonin (PCT) levels after uncomplicated cardiac surgery, characterising the role of PCT as a tool in discriminating infection, identifying the relation between PCT, organ failure, and severity of sepsis syndromes, and assessing the possible role of PCT in detection of postoperative complications and mortality.

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Procalcitonin: present and future

et al. 2015

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Critically ill patients are frequently at risk of sepsis or inflammatory conditions. Procalcitonin (PCT) is a biomarker for critically ill patients to differentiate sepsis from non-infectious triggers of the systemic inflammatory response syndrome. It has been recently shown that PCT is a valuable tool to guide antibiotic treatment in patients with bacteria infections. However, PCT is also less than a universal and perfect biomarker, and its physiologic role remains unknown. An increase in PCT is associated not only with localized bacterial infection, but also with non-infectious disease or other microbial infections. Numerous studies have suggested that use of PCT would reduce patients' exposure to antibiotics; however, the use of PCT-guided management of antibiotics strategy needs further study to validate their safety in daily practice in ICU settings. Data supporting this concept from randomized trials are still required. Future studies should focus on PCT kinetics. On the other hand, the need for biologic role of PCT shall be highlighted. Immunoneutralization of PCT will likely be a therapeutic approach for human sepsis only if its physiologic effects are elaborated. The aim of this review is to summarize and discuss the current evidence for PCT in a series of clinical settings.

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Procalcitonin is useful whereas C-reactive protein is not, to predict complications following coronary artery bypass surgery

Abstract: A postoperative serum PCT concentration of >0.5 ng/mL is highly suggestive of a postoperative complication. CRP changes do not contribute to predictive information.

Cited by 20 publications

References 23 publications

Comparison of procalcitonin and CrP in the postoperative course after lung decortication

Comparison of procalcitonin and CrP in the postoperative course after lung decortication

Diagnostic value and prognostic implications of serum procalcitonin after cardiac surgery: a systematic review of the literature

Procalcitonin: present and future

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