Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis

Yadav, P. S.; Agarwal, Krishna; Rani, Anita; Dewan, Rupali; Chellani, Harish

doi:10.1016/j.eurox.2023.100221

European Journal of Obstetrics & Gynecology and Reproductiv

2023

DOI: 10.1016/j.eurox.2023.100221

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Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis

P. S. Yadav

Krishna Agarwal

Anita Rani

et al.

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2024

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Fetal chronic hypoxia does not affect urinary presepsin levels in newborns at birth

D’Adamo,

Levantini,

Librandi

et al. 2024

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives Early sepsis detection and diagnosis still constitutes an open issue since the accuracy of standard-of care parameters is biased by a series of perinatal factors including hypoxia. Therefore, we aimed at investigating the effect of fetal chronic hypoxia insult on urine levels of a promising new marker of sepsis, namely presepsin (P-SEP). Methods We conducted a prospective case-control study in 22 cases of early-intrauterine growth restriction (E-IUGR) compared with 22 small-for-gestational-age (SGA) newborns and 66 healthy controls. P-SEP urine samples were collected over the first 72 h from birth. Blood culture and C-reactive protein (CRP) blood levels were measured in E-IUGR and SGA infants. Perinatal standard monitoring parameters and main outcomes were also recorded. Results No significant urinary P-SEP differences (p>0.05, for all) were observed among studied groups. Moreover, no significant correlations (p>0.05, for both) between urinary P-SEP and blood CRP levels in both E-IUGR and SGA groups (R=0.08; R=0.07, respectively) were observed. Conclusions The present results showing the lack of influence of fetal chronic hypoxia on urinary P-SEP levels offer additional data to hypothesize the possible use of urinary P-SEP measurement in neonates in daily clinical practice. Further multicenter prospective data are needed, including infants with early-onset sepsis.

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Fetal chronic hypoxia does not affect urinary presepsin levels in newborns at birth

D’Adamo,

Levantini,

Librandi

et al. 2024

Clinical Chemistry and Laboratory Medicine (CCLM)

View full text Add to dashboard Cite

show abstract

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Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis

Cited by 1 publication

References 21 publications

Fetal chronic hypoxia does not affect urinary presepsin levels in newborns at birth

Fetal chronic hypoxia does not affect urinary presepsin levels in newborns at birth

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