Procalcitonin (PCT) in patients with abdominal sepsis

Abstract

Procalcitonin is a new indicator of infection and sepsis. TNF and IL-6 concentrations always rise after major operations and fall in the absence of infection, indicating operative trauma. Procalcitonin is sensitive in detecting infective complications. Under routine conditions the procalcitonin concentrations seems to be valid, reproducible and detectable.

The prognostic value of Pro-Calcitonin, CRP and thyroid hormones in secondary peritonitis;A single-center prospective study

“…In spite of this, PCT was described to be more sensitive in sepsis and bacterial infections. [15] Ulus Travma Acil Cerrahi Derg, September 2014, Vol. 20, No.…”

Evaluation of Procalcitonin for Predicting Septic Multiorgan Failure and Overall Prognosis in Secondary Peritonitis

“…Hence, it has been largely confirmed that procalcitonin is the only one in a large array of biochemical markers that closely correlates with the inflammatory host response to microbial infections. 26,27 In peritonitis, only 2 studies 22,23 have ever been conducted, to our knowledge, investigating the usefulness of procalcitonin in monitoring the postoperative course after surgical treatment. Both studies 22,23 have shown that procalcitonin is a reliable indicator of nonsurvival.…”

“…In contrast, biochemical variables for stratifying disease severity in secondary peritonitis are poorly studied, with inconclusive results due to noncomparable study populations and nonstandardized assay techniques. [15][16][17][18][19][20][21][22][23] Up-to-date, critical care-derived scoring systems and biochemical markers have not been shown to be reliable for indicating infection and associated sepsis in patients with secondary peritonitis. 24 Currently, radiologic imaging procedures (eg, contrast-enhanced computed tomography) and guided aspiration techniques (eg, fine-needle aspiration) are frequently used to diagnose septic abdominal complications.…”

Management of Intra-Abdominal Infections

“…Kinetic studies demonstrated CRP levels elevate on post-operative day (POD) 1, peak from POD2 to POD3, and decline by POD5 provided that there is no complication or infection. Four reports suggest a persistent threshold of greater than 100 mg/L might indicate abscess/septic complications [254][255][256][257]; other studies have refuted this conclusion, leaving uncertainty for clinical utility [258][259][260][261][262].…”