Procalcitonin Versus C-Reactive Protein for Guiding Antibiotic Therapy in Sepsis

Oliveira, Carolina; Botoni, Fernando Antônio; Oliveira, Clara Rodrigues Alves de; Silva, Camila B.; Pereira, Héléna; Serufo, José Carlos; Nobre, Vandack

doi:10.1097/ccm.0b013e31828e969f

Cited by 176 publications

(147 citation statements)

References 38 publications

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“…We referred to 9 RCT reports during our meta‐analysis on this topic 78, 79, 80, 81, 82, 83, 84, 85, 86. No significant differences were observed between the intervention and control groups with respect to ICU stay time, hospitalization period, 60‐day mortality rate, and 90‐day mortality rate.…”

Section: Introductionmentioning

confidence: 99%

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Nishida

Ogura

Egi

et al. 2018

Acute Medicine & Surgery

157

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Background and PurposeThe Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016), a Japanese‐specific set of clinical practice guidelines for sepsis and septic shock created jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in February 2017 in Japanese. An English‐language version of these guidelines was created based on the contents of the original Japanese‐language version.MethodsMembers of the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine were selected and organized into 19 committee members and 52 working group members. The guidelines were prepared in accordance with the Medical Information Network Distribution Service (Minds) creation procedures. The Academic Guidelines Promotion Team was organized to oversee and provide academic support to the respective activities allocated to each Guideline Creation Team. To improve quality assurance and workflow transparency, a mutual peer review system was established, and discussions within each team were open to the public. Public comments were collected once after the initial formulation of a clinical question (CQ), and twice during the review of the final draft. Recommendations were determined to have been adopted after obtaining support from a two‐thirds (>66.6%) majority vote of each of the 19 committee members.ResultsA total of 87 CQs were selected among 19 clinical areas, including pediatric topics and several other important areas not covered in the first edition of the Japanese guidelines (J‐SSCG 2012). The approval rate obtained through committee voting, in addition to ratings of the strengths of the recommendation and its supporting evidence were also added to each recommendation statement. We conducted meta‐analyses for 29 CQs. Thirty seven CQs contained recommendations in the form of an expert consensus due to insufficient evidence. No recommendations were provided for 5 CQs.ConclusionsBased on the evidence gathered, we were able to formulate Japanese‐specific clinical practice guidelines that are tailored to the Japanese context in a highly transparent manner. These guidelines can easily be used not only by specialists, but also by non‐specialists, general clinicians, nurses, pharmacists, clinical engineers, and other healthcare professionals.

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Section: Introductionmentioning

confidence: 99%

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

Nishida

Ogura

Egi

et al. 2018

Acute Medicine & Surgery

157

View full text Add to dashboard Cite

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“…In a French study (25) on non-surgical patients with suspected bacterial infection (73% with a respiratory infection) in seven ICUs, PCT-guided treatment initiation and discontinuation provided 23% more antibiotic free days compared to the control group (25). On the other hand, in a RCT in two Brazilian ICUs, a CRP-based algorithm was compared to a PCT-based algorithm in patients with severe sepsis and septic shock and CRP-based algorithm was found to have similar success (26). In our study, we observed that there is a moderate correlation between PCT versus SOFA and CRP versus SOFA at the antibiotic change day.…”

Section: Characteristics N=176mentioning

confidence: 97%

The Characteristics of Antibiotic Use and Changing Patterns in an Intensive Care Unit

Kara¹,

Sahar²,

Güllü³

et al. 2016

Yoğun Bakim Derg

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“…In fulminant disease courses, the CRP induction time (response-HT after stimulus 6-10 h, relative increase 10-100-fold) means that septic shock can already be present before laboratory analysis detects an increase in the CRP value. CRP is, however, of value for evaluation of disease course and monitoring of treatment efficiency [59,67]. Persistent increases in CRP level or a secondary increase in plasma concentration in patients on anti-infective therapy may indicate inadequate control of the infection (e. g., infectious complications, secondary infections, polymicrobial infections, MDR pathogens, ineffective antibiotic, inadequate antibiotic dosage; [59]).…”

Section: C-reactive Proteinmentioning

confidence: 99%

Bacterial sepsis

et al. 2018

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Procalcitonin Versus C-Reactive Protein for Guiding Antibiotic Therapy in Sepsis

Abstract: C-reactive protein was as useful as procalcitonin in reducing antibiotic use in a predominantly medical population of septic patients, causing no apparent harm.

Cited by 176 publications

References 38 publications

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG2016)

The Characteristics of Antibiotic Use and Changing Patterns in an Intensive Care Unit

Bacterial sepsis

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