Background Cases where traditional PCI is insufficient to manage complex and high-risk lesions. In recent times, use of extracorporeal membrane oxygenation (ECMO) during PCI emerged as potential solution to manage complex and high-risk lesions. Methods Retrospective study patients elective high-risk PCI with hemodynamic support provided VA-ECMO (2018-2022). Complications related to VA-ECMO rates, Complications related to PCI, death, and major cardiovascular, cerebral events during hospital stay and 1-year follow-up were analyzed. Results This retrospective study included 81 patients Average age: 62.74 ±10.807 years underwent high-risk PCI assisted ECMO.VA-ECMO for an average of 21.0 hr. Intra-aortic Balloon Pump IABP support in 32.1% patients. Pre-and post-PCI SYNTAX scores 39.92 ± (6.4) and 6.04 ± (9.25) respectively. (P <0.001). Most patients had triple-vessel coronary disease. Interoperated complications Cardiac Tamponade (N=1, 1.2%), Acute Myocardial Infarction (N=6, 7.2%), Cardiogenic Shock (N=2, 2.4%), Cardiac Arrest (N=2, 2.4%), Aortic Dissection Type-A (N=1, 1.2%). Blood hemoglobin Pre- and Post-PCI 136.17 ± 21.479 g/L and 106.67 ± 19.103 g/L respectively P<0.001). eGFR pre- and post-PCI 67.22 ± 26.85 and 60.09 ± 27.78 respectively (p<0.002), Pre and Post PCI EF were 38.69 ± 13.65 and 43.55 ± 13.72 respectively (p<0.001), Clinical Outcomes, Survival at discharge Healthy was (N=65, 80.2%), Death (N=16,19.8%) No lower limb ischemia, No acute renal injury, no bacteremia during hospitalization. 1-year post-operation death (N=6, 7.2%) Conclusion In conclusion, ECMO-assisted high-risk PCI proves to be a safe and effective strategy for complex procedures in patients who are not candidates for Coronary artery bypass grafting.