Procedures for Model-Guided Data Analysis of Chromosomal Loci Dynamics at Short Time Scales

Lagomarsino, Marco Cosentino

doi:10.1007/978-1-4939-7098-8_21

Cited by 1 publication

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“…In addition, the contribution of chromosome folding to subdiffusion is an open question [6,14,15]. In this context, a phenomenological model realizing the main pertinent features can be an useful first step [16].…”

Section: Introductionmentioning

confidence: 99%

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Model of chromosomal loci dynamics in bacteria as fractional diffusion with intermittent transport

2017

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The short-time dynamics of bacterial chromosomal loci is a mixture of subdiffusive and active motion, in the form of rapid relocations with near-ballistic dynamics. While previous work has shown that such rapid motions are ubiquitous, we still have little grasp on their physical nature, and no positive model is available that describes them. Here, we propose a minimal theoretical model for loci movements as a fractional Brownian motion subject to a constant but intermittent driving force, and compare simulations and analytical calculations to data from high-resolution dynamic tracking in E. coli. This analysis yields the characteristic time scales for intermittency. Finally, we discuss the possible shortcomings of this model, and show that an increase in the effective local noise felt by the chromosome associates to the active relocations.

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Section: Introductionmentioning

confidence: 99%

“…It is well known that in the case of viscoelastic subdiffusion, an object under constant driving force has to produce a sublinear mean-square displacement (drift), in order to follow a fluctuation-dissipation relation [16][17][18]. This constraint is realized by the fractional Langevin equation [17,19,20].…”

Section: Introductionmentioning

confidence: 99%