Proceedings: initiation of implantation in the mouse with anterior pituitary hormones

Gidley-Baird, AA

doi:10.1530/jrf.0.0430387

Cited by 1 publication

(3 citation statements)

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“…Levels of FSH in the plasma reach a peak on day 3 of pseudopregnancy in the rat, which would be consistent with a controlling influence on the secretion of luteal-phase estrogen. Probably the recent replacement experiments by Gidley-Baird and Emmens (1975) summarize the present information most clearly. They found that a combination of prolactin and FSH is all that is required for the initiation of implantation in hypophysectomized mice, but that the addition of LH augmented the effectiveness of the two hormones.…”

Section: Role Of the Pituitary And Hypothalamusmentioning

confidence: 78%

“…They suggested that LH stimulated estrogen secretion from the luteinized ovaries. Other workers, however, have produced evidence that FSH is the principal hormone involved (Raud, 1974;Gidley-Baird and Emmens, 1975;Watson et at., 1975). Levels of FSH in the plasma reach a peak on day 3 of pseudopregnancy in the rat, which would be consistent with a controlling influence on the secretion of luteal-phase estrogen.…”

Section: Role Of the Pituitary And Hypothalamusmentioning

confidence: 99%

“…The evidence at present suggests that small quantities of LH support the luteotrophic action of prolactin. In hypophysectomized mice it is possible to initiate implantation without LH, but when it is included in the replacement therapy, lower doses of prolactin are effective (Gidley-Baird and Emmens, 1975).…”

Section: Role Of the Pituitary And Hypothalamusmentioning

confidence: 99%

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The Implantation Reaction

Finn

1977

Biology of the Uterus

171

121

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Implantation involves the attachment of the blastocyst to the wall of the uterus with, in some cases, the embedding of the entire ovum in the uterine wall. Associated with it are very profound and characteristic changes in the endometrium both during preparation for implantation and following attachment of the blastocyst. In this chapter, the uterine changes that take place during preparation will be considered first and then the changes during the process of implantation. The former occur regularly and frequently throughout the life of most female mammals, whereas the latter are rarer events, especially in women. This division of the subject is also convenient for the consideration of the control mechanism involved. Whereas the preparative changes are largely directed by the varying levels of the hormones secreted by the ovary, once the implantation process has been initiated hormones playa largely permissive role.There is considerable species variation in the reaction of the uterus in preparation for and during implantation. De Feo (1967) reviewed this subject very thoroughly in the first edition of this book. The great majority of research investigations have been carried out on laboratory rodents, with very little on primates or the larger domestic animals. It follows therefore that any general account of implantation will lean heavily on information acquired from laboratory animals. Although one would like to have a much more general coverage, one cannot escape the reality that information acquired from many experiments on large numbers of laboratory animals provides a sound foundation on which to build. Information from primates or wild mammals will always tend to be fragmentary because of the difficulty of obtaining large numbers of specimens. Anyone who has worked with rats or mice knows how easy it is to be misled by the results from two or three animals. The only sensible course therefore is to get as

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Section: Role Of the Pituitary And Hypothalamusmentioning

confidence: 78%

Section: Role Of the Pituitary And Hypothalamusmentioning

confidence: 99%