“…It is well documented that obesity is a risk factor for many disorders in dogs, such as orthopaedic disease (Kealy et al ., ), urinary tract disease (Lekcharoensuk et al ., ; Lund et al ., ), cardiovascular disease (Edney & Smith, ; Mizelle et al ., ), respiratory dysfunction (Bach et al ., ) and hormonal disturbances (Martin et al ., ). Taken together, obesity reduces longevity (Kealy et al ., ) and has to be regarded as an animal welfare issue (Houpt et al ., ). Although the treatment of obesity, reducing energy intake and enhancing physical activity are simple in theory, weight loss programs often fail; therefore, a better knowledge about the underlying pathogenetic mechanisms is urgently needed.…”