Proceedings of the 2013 National Toxicology Program Satellite Symposium

Elmore, Susan A.; Boyle, Michael C.; Boyle, Molly H.; Cora, Michelle; Crabbs, Torrie A.; Cummings, Connie A.; Gruebbel, Margarita M.; Johnson, Crystal L.; Malarkey, David E.; McInnes, Elizabeth F.; Nolte, Thomas; Shackelford, Cynthia C.; Ward, Jerrold M.

doi:10.1177/0192623313508020

Cited by 8 publications

(8 citation statements)

References 102 publications

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“…In general, apoptotic cells occur as single, noncontiguous cells or small clusters of cells alone or scattered within a tissue section (Figure 9; Table 1) (Elmore et al 2014). However, experimental induction can result in massive apoptosis of all or most cells (Figure 10).…”

Section: Recommendations For Cell Death Nomenclature Apoptosismentioning

confidence: 99%

“…Tingible body macrophages are not a feature in the liver, presumably due to the fast and efficient removal of cell debris by Kupffer cells. Previously published in Toxicologic Pathology ; Elmore et al (2014) Jan;42(1):12-44.…”

Section: Figurementioning

confidence: 99%

“…There is marked cell swelling and karyorrhexis in a necrotic hepatocyte (arrow) and a nearby small focus of inflammation (arrowhead), most likely secondary to cell rupture. Previously published in Toxicologic Pathology ; Elmore et al (2014) Jan;42(1):12-44.…”

Section: Figurementioning

confidence: 99%

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Recommendations from the INHAND Apoptosis/Necrosis Working Group

et al. 2016

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Historically, there has been confusion relating to the diagnostic nomenclature for individual cell death. Toxicologic pathologists have generally used the terms single cell necrosis and apoptosis interchangeably. Increased research on the mechanisms of cell death in recent years has led to the understanding that apoptosis and necrosis involve different cellular pathways and that these differences can have important implications when considering overall mechanisms of toxicity, and, for these reasons, the separate terms of apoptosis and necrosis should be used whenever differentiation is possible. However, it is also recognized that differentiation of the precise pathway of cell death may not be important, necessary, or possible in routine toxicity studies and so a more general term to indicate cell death is warranted in these situations. Morphological distinction between these two forms of cell death can sometimes be straightforward but can also be challenging. This article provides a brief discussion of the cellular mechanisms and morphological features of apoptosis and necrosis as well as guidance on when the pathologist should use these terms. It provides recommended nomenclature along with diagnostic criteria (in hematoxylin and eosin [H&E]-stained sections) for the most common forms of cell death (apoptosis and necrosis). This document is intended to serve as current guidance for the nomenclature of cell death for the International Harmonization of Nomenclature and Diagnostic Criteria Organ Working Groups and the toxicologic pathology community at large. The specific recommendations are: Use necrosis and apoptosis as separate diagnostic terms. Use modifiers to denote the distribution of necrosis (e.g., necrosis, single cell; necrosis, focal; necrosis, diffuse; etc.). Use the combined term apoptosis/single cell necrosis when There is no requirement or need to split the processes, or When the nature of cell death cannot be determined with certainty, or When both processes are present together. The diagnosis should be based primarily on the morphological features in H&E-stained sections. When needed, additional, special techniques to identify and characterize apoptosis can also be used

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Section: Recommendations For Cell Death Nomenclature Apoptosismentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Recommendations from the INHAND Apoptosis/Necrosis Working Group

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“…Lipofuscin may also be found within alveolar macrophages. Inert materials such as corn oil accidentally instilled into the lung during gavage procedures, may also be visible in the lung (Elmore et al, 2014).…”

Section: Pigmentsmentioning

confidence: 99%

Lung, Pleura, and Mediastinum

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Janardhan

Pandiri

et al. 2018

Boorman's Pathology of the Rat

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“…The National Toxicology Program (NTP) Satellite Symposium is a 1-day meeting that has traditionally been held in conjunction with the annual Society of Toxicologic Pathology (STP) meeting (Adams et al 2011; Bach et al 2010; Boorman et al 2012; Elmore et al 2013, 2014, 2015, 2016). The objective of this annual symposium is to provide continuing education on interpreting histopathology slides.…”

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confidence: 99%

Proceedings of the 2016 National Toxicology Program Satellite Symposium

et al. 2016

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The 2016 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri” was held in San Diego, California, at the Society of Toxicologic Pathology’s (STP) 35th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks, along with select images that were used by the audience for voting and discussion. Some lesions and topics covered during the symposium included malignant glioma and histiocytic sarcoma in the rodent brain; a new statistical method designed for histopathology data evaluation; uterine stromal/glandular polyp in a rat; malignant plasma cell tumor in a mouse brain; Schwann cell proliferative lesions in rat hearts; axillary schwannoma in a cat; necrosis and granulomatous inflammation in a rat brain; adenoma/carcinoma in a rat adrenal gland; hepatocyte maturation defect and liver/spleen hematopoietic defects in an embryonic mouse; distinguishing malignant glioma, malignant mixed glioma and malignant oligodendroglioma in the rat; comparison of mammary gland whole mounts and histopathology from mice; and discussion of the International Harmonization of Nomenclature and Diagnostic Criteria (INHAND) collaborations.

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Proceedings of the 2013 National Toxicology Program Satellite Symposium

Cited by 8 publications

References 102 publications

Recommendations from the INHAND Apoptosis/Necrosis Working Group

Recommendations from the INHAND Apoptosis/Necrosis Working Group

Lung, Pleura, and Mediastinum

Proceedings of the 2016 National Toxicology Program Satellite Symposium

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