Proceedings of the 2019 National Toxicology Program Satellite Symposium

Abstract

The 2019 annual National Toxicology Program Satellite Symposium, entitled “Pathology Potpourri,” was held in Raleigh, North Carolina, at the Society of Toxicologic Pathology’s 38th annual meeting. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks along with select images that were used by the audience for voting and discussion. Various lesions and topics covered during the symposium included aging mouse lesions from various strains, as well as the following lesions from various rat strains: rete testis sperm granuloma/fibrosis, ovarian cystadenocarcinoma, retro-orbital schwannoma, periductal cholangiofibrosis of the liver and pancreas, pars distalis hypertrophy, chronic progressive nephropathy, and renal tubule regeneration. Other cases included polyovular follicles in young beagle dogs and a fungal blood smear contaminant. One series of cases challenged the audience to consider how immunohistochemistry may improve the diagnosis of some tumors. Interesting retinal lesions from a rhesus macaque emphasized the difficulty in determining the etiology of any particular retinal lesion due to the retina’s similar response to vascular injury. Finally, a series of lesions from the International Harmonization of Nomenclature and Diagnostic Criteria Non-Rodent Fish Working Group were presented.

Historical Controls in Randomized Clinical Trials: Opportunities and Challenges

“…These “big data” approaches range from cross‐industry initiated placebo and standard of care (TransCelerate), 3,97 and the Synthetic Control Database (from Medidata) to “in‐house” datasets, such as the one used by AbbVie 98 . In recognition of the power of historical controls to accelerate drug discovery, there are even non‐human studies like the National Toxicology Program Historical Controls database for genetically modified models 99 …”

“…98 In recognition of the power of historical controls to accelerate drug discovery, there are even non-human studies like the National Toxicology Program Historical Controls database for genetically modified models. 99 Arguably, the greatest threat to use of historical controls derives from the potential for selection bias and confounding. Hence, utility of historical controls calls for comprehensive representation of data from the totality of clinical trials for a given indication, raising considerable concerns with conflict of interest.…”

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Dog

“…102 Dog-specific peculiarities in the reproductive physiology include the presence of polyovular follicles, ovulation of an immature oocyte, and a periovulatory period with particularly high concentrations of circulating progesterone. 129 –131…”

“…102 Dog-specific peculiarities in the reproductive physiology include the presence of polyovular follicles, ovulation of an immature oocyte, and a periovulatory period with particularly high concentrations of circulating progesterone. [129][130][131] In the female dog, the ovary, uterus, cervix, and vagina show marked cyclical changes, which are displayed in Table 11.1. For easy reference, the cycle changes in the mammary gland are included as well.…”

Spontaneous cholangiofibrosis adjacent to a dilated common bile duct with intestinal metaplasia in a Royal College of Surgeons rat

“…Our case resembled Chen’s case of spontaneous cholangiofibrosis, except for continuity to a dilated common bile duct with intestinal metaplasia and hepatic parenchyma retained in the peripheral area. Recently, in the proceedings of the 2019 National Toxicology Program Satellite Symposium, spontaneous cholangiofibrosis in the liver and pancreas of untreated Hsd:Sprague Dawley (SD) rats was reported 10 . This case had histopathological descriptions similar to those of xenobiotic-induced cholangiofibrosis, but was different owing to the singular distribution and close proximity to a large bile duct.…”