Proceedings of the Australasian Society of Clinical and Experimental Pharmacologists

Abstract

1. The development of the prejunctional receptor hypothesis. M.W. McCulloch, M.J. Rand and D. F. Story2. Adrenoceptor‐ and cholinoceptor‐mediated modulation of transmitter release at the somatic neuromuscular junction. C. Raper3. Conditions of operation of positive and negative feedback regulation of transmitter noradrenaline release. D.F. Story and I.C. Medgett4. Failure of a receptor blockade–a pre‐ and post‐synaptic phenomenon. G.D.S. Hirst and T.O. Neild5. Are radioligand assays useful for identification and characterization of prejunctional receptors? R.J. Summers and B. Jarrott6. Prejunctional modulation of postganglionic cholinergic nerves. F. Mitchelson7. Opiate receptor modulation of transmitter release. J.E. Olley* and A.L.A. Boura8. Prejunctional receptors of human vascular sympathetic nerves. R.F. W. Moulds9. Clinical implications of autonomic prejunctional receptors. J. Shaw10. Correlations between the antihypertensive and haemodynamic effects of oxprenolol. R. Zacest, M.A. Robinson and L.L. Wilson11. Comparison of long acting and short acting diuretics in mild essential hypertension. L.M.H. Wing, M.J. West, J.R. Graham and J.P. Chalmers12. Effects on heart rate and blood pressure during graded exercise of beta adrenoceptor blocking drugs with and without intrinsic sympathomimetic activity (ISA) or ‘cardio‐selectivity’. G. Jennings, A. Bobik, P. Ashley, R. Newman, S. Ellet and P. Korner13. Study of the effects of acute dosing with ac‐methyl dopa on reflex autonomic tachycardia. A.J. McLean, G. Jennings and P.I. Korner14. A study of in vitro vasoactivity of C.S.I, and the clinical state of patients who have had a subarachnoid haemorrhage. R.F.W. Moulds, C. Mylonas, R. Medcalfand D. Brownbill15. Retrospective survey of digoxin usage. C. Corallo and K. Raymond16. Dihydroergotamine kinetics in patients with orthostatic hypotension. A. Bobik, H. Skews, G. Jennings, M. Esler and P.I. Korner17. Effect of probenecid on clofibrate disposition in man. J.R. Veenendaal. P.M. Brook and P.J. Meffin18. Pharmacokinetics in human malnutrition. N. Buchanan19. Impairment of an hepatic protective mechanism in man by food ingestion. A.J. McLean, C. Isbister, A. Bobik and F.J. Dudley20. Carbamazepine monotherapy in epileptic patients. G.W. Mihaly and F.J.E. Vajda21. Simultaneous determination of aspirin, salicyclic acid, salicyluric acid and gentisic acid in plasma by HPLC. R.H. Rumble and M.S. Roberts22. Association between angiotensin conversion and prostacyclin release in isolated mesenteric vasculature of rats. G.J. Dusting and E.M. Mullins23. Prostacyclin inhibits contractions of the rat isolated descending colon in response to field stimulation. I.R.N. Relf and A.L.A. Boura24. Bradykinin induced spasm of the human umbilical vein is mediated via activation of phospholipase‐A and potentiated by cooling. A.L.A. Boura, A.S.C. Sandford, R.J. McRae and W.A.W. Walters25. L‐Tryptophan‐induced depression of α‐adrenoceptor mediated vascular responses in the rat. P.L. Nolan and J.W. Caygill26. Evidence against a physiological role of presynaptic alpha adrenoceptors in heart. J.A. Angus and P.I. Korner27. The effect of DOCA hypertension on responses of the rat tail artery to potassium chloride and electrical stimulation. M.G. Venning and I.S. de la Lande28. A possible histaminergic component of the clonidine withdrawal syndrome in the rat. S.J. Lewis, M.R. Fennessy and D.A. Taylor29. Clonidine withdrawal syndrome and endogenous biogenic amines. D.A. Taylor, S.J. Lewis and M.R. Fennessy30. The effects of sub‐acute L‐DOPA treatment of mice on L‐DOPA‐induced hyperactivity. O. Jenkins, R. Bailey, E. Crisp and D.M. Jackson31. Chronic L‐DOPA pretreatment of mice: production of dopamine receptor supersensitivity? R. Bailey, E. Crisp, D.M. Jackson and O. Jenkins32. Accumulation of α‐methylated phenolamines in rat brain after chronic administration of a‐methyltyrosine. P.H. Duffield, D.F.H. Dougan, D.N. Wade and A.M. Duffield33. Effect of unilateral lesions on octopamine and tyramine concentrations in rat striatum. D.F.H. Dougan, P.H. Duffield, D.N. Wade, A.M. Duffield and G. Paxinos34. Effect of surgical denervation on α1 and α2‐adrenoceptors in rat cerebral cortex. M.J. Morris, J.L. Elghozi, J.P. Dausse and P. Meyer35. Localization of |3H|clonidine binding sites in membranes prepared from guinea pig renal cortex. G. McPherson and R.J. Summers36. Characterization of (3H)cIonidine binding sites in membranes prepared from guinea pig spleen. R.J. Summers and G. McPherson37. Alpha‐adrenergic receptors modulate agonist affinity for beta‐receptors in rat kidney membranes. E.A. Woodcock and C.A. Olsson38. Pentobarbitone enhancement of GABA binding. M. Willow and G.A.R. Johnston39. Stress induced changes in Leucine‐enkephalin binding and plasma corticosterone in mice. M.J. Christie, P. Trisdikoon, J. Eross and G.B. Chesher40. Duration of the analgesic effects of some opiate‐like peptides following intracerebroven‐tricular (i.c.v.) administration in the rat. M.J. Quinn and M.R. Fennessy41. Relationship between δ9‐tetrahydrocannabinol (δ9‐THC) withdrawal behaviour and brain regional levels of histamine (HA) in the rat. A.J.M. Verberne, D.A. Taylor, S.J. Lewis and M.R. Fennessy42. Long‐term effects of a single dose of haloperidol or thioridazine on schedule induced drinking. G. Singer44. Effect of o‐methylflavinantine on contractions of the guinea‐pig longitudinal muscle induced by co‐axial electrical stimulation. R. Ansa‐Asamoah and G.A. Starmer45. Do endogenous purine nucleosides modulate the release of acetylcholine at the mammalian neuromuscular junction? I. Spence46. Effect of adrenaline on transmitter noradrenaline release. H. Majewski, M.W. McCulIoch, M.J. Rand and D.F. Story47. Effects of tetrodotoxin on release of noradrenaline by nicotine in rabbit atria. C. Sarantos‐Laska, M.W. McCulloch, D.F. Story and M.J. Rand48. The effect of ventilatory gas composition on arachidonic acid metabolism in isolated perfused guinea‐pig lungs. V. Iwanov, J. Staszewska‐Barczak and G.J. Dusting49. An isolated perfused adrenal preparation for studying adrenal catecholamine secretion. A.R. Collett and D.F. Story50. Inhibition of nerve‐mediated contractions in isolated guinea‐pig ileum by 1‐methyliso‐guanosine, a novel purine from a sponge. D. Jamieson and P. Davis53. β‐Adrenoceptors and catecholamine‐induced responses of human and porcine peripheral lung strip: Effects of uptake inhibitors. R.G. Goldie and G.M. Ellis54. Uptake and release of N‐methyl‐D‐aspartate by rat brain slices. J.H. Skerritt and G.A.R. Johnston62. Receptor binding assay for detection of endogenous opioids. P.M. Lewis and J.E. Olley63. Prospective drug utilization study of antibiotics based on blood level assays. A. Saunders and K. Raymond57. The pharmacokinetics of chlorbutol. C. Tung, G.G. Graham, D.N. Wade and K.M. Williams58. Effect of desmethylimipramine on the anorectic activity and tissue distribution of chlorphentermine in rats. R.F. Minchin, K.F. Ilett and B.W. Madsen59. Effects of a new monoamine oxidase‐A selective inhibitor (MD780515) on amine metabolism in the small intestine. K.F. Ilett, C.F. George and D.S. Davies60. Hepatic elimination of sodium valproate (SV). F.J.E. Vajda, A.W. Marshall, G.W. Mihaly, R.A. Smallwood, J. Baldas and J. Phillips61. A sensitive method for measurement of catecholamines and their metabolites in extracts of small brain areas. P.R. Rowe, R.J. Summers and P.M. Beart62. Receptor binding assay for detection of endogenous opioids. P.M. Lewis and J.E. Olley63. Prospective drug utilization study of antibiotics based on blood level assays. A. Saunders and K. Raymond64. Gastric absorption of valproate in rats. N.D. Yeomans, F.J.E. Vajda and J. Baldas65. Elimination kinetics of labetalol in severe renal failure. D.G. Ferry, A.J. Wood and R.R. Bailey66. High pressure liquid chromatographic analysis of ranitidine. G.W. Mihaly, O.H. Drummer, A.W. Marshall, W.J. Louis and R.A. Smallwood67. Model independent pharmacokinetics of slow intravenous infusions. K. Raymond and D.J. Morgan68. Fate of oral hydrallazine in slow and fast acetylators. I. Cozamanis, P.A. Reece and R. Zacest69. Pharmacokinetics of perhexiline maleate in patients with angina pectoris. J.D. Horowitz, P.M. Morris, A.J. Goble and W.J. Louis70. The pharmacokinetics of midazolam in man. M.T. Smith, M.J. Eadie, T. O'Rourke‐Brophy and T.C. Smith71. The perinatal disposition of thiopentone. L. Wolf, D.J. Morgan, G.L. Blackman and J.D. Paull72. Minor metabolites of 5‐fluorocytosine in man. K.M. Williams, A.M. Duffield, R.K. Christopher and P.J. Finlayson73. Steady‐state bioavailability of a slow release theophylline formulation in children with acute asthma. D.J. Birkett, K. Coulthard, J.O. Miners, J.J. Grygiel, N. Grgurinovich and D. Lines74. Protein binding of non‐steroidal anti‐inflammatory drugs in rheumatoid arthritis. S. Wanwimolruk, D.J. Birkett and P. Brooks75. The measurement of mouth‐caecal transit time using salicylazosulphapyridine. E.J. Begg, M. Kennedy, P.M. Chinwah and D.N. Wade76. Mechanisms of acute hypertension and bradycardia following intracisternal 6‐hydroxy‐dopamine in conscious rabbits. G.A. Head and P.I. Koraer77. Effects of dopamine on renal function and kallifrein excretion in the isolated perfused rat kidney. B.P. McGrath, P.G. Matthews, L. Leversha, P. Jablonski and B. Howden78. A comparison of the effects of Endrallazine and Hydralazine on isolated human arteries and veins. S. Lipe, R. Medcalf, V. Iwanov and R.F.W. Moulds79. Studies on amphetamine‐induced circling in rats with substantia nigra lesions. J.S. McKenzie, S. Hannigan and A. Churchyard80. Further studies on the peripheral antinociceptive action of morphine. G.A. Bentley, S.H. Newton and Jennifer Starr81. Chronic haloperidol treatment of rats and a‐adrenergic receptor sensitivity. A. Per ring‐ton, R. Einstein and D.M. Jackson82. Anticonvulsant activity of propranolol. Jenny Papanicolaou, F.J.E. Vajda and W.L Louis83. Glycine and dopamine in the ventral tegmental area of the rat. A.L. Gundlach, D. McDonald and P.M. Beart84. Effects of beta‐adrenoceptor antagonists on the haemoglobin‐oxygen (Hb‐O) dissociation curve in vitro and in vitro. P.W. Trembath, E.A. Taylor, M. Roberts, and J. Amess85. Clonidine analogues and hypothermia in mice. P.L. McLennar86. Myolytic effects of Australian snake venoms in monkeys (Macaca fascicularis). S.K. Sutherland and D.G. Campbell87. Prevention of sulphur‐induced bronchoconstriction by disodium cromoglycate (DSCG) and Ketotifen. Diana M. Temple