Proceedings of The Biochemical Society

Abstract

PROCEEDINGS OF THE BIOCHEMICAL SOCIETY kinase also occurs outside the nervous system and its subcellular distribution suggests that it may be a plasma membrane component (Michell & Hawthorne, 1965). The kinase forming triphosphoinositide, on the other hand, appears largely in the supernatant fraction (Kai, Salway, Michell & Hawthorne, 1966). Direct evidence linking diphosphoinositide and triphosphoinositide with nerve excitation is lacking. These lipids are not directly involved in sodium transport (Dawson, 1965). A number of facts suggest that they might affect the permeability of the neuronal membrane and thus the action potential, through their ability to complex with