Proceedings of the First International Optogenetic Therapies for Vision Symposium

Francis, Peter J.; Mansfield, Brian C.; Rose, Steven

doi:10.1167/tvst.2.7.4

Cited by 15 publications

(10 citation statements)

References 60 publications

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“…With the combined use of these proteins and specific light wavelengths, it is possible to study the behavior of a specific area of the human brain in different conditions [6]. The first trials involving optogenetic techniques were carried out in the field of ophthalmology [7]. These trials mainly involved the Opsins family.…”

Section: Molecular Pathways In Optogeneticsmentioning

confidence: 99%

The Impact of Optogenetics on Regenerative Medicine

Spagnuolo

Genovese²,

Lombardo

et al. 2019

Applied Sciences

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Optogenetics is a novel strategic field that combines light (opto-) and genetics (genetic) into applications able to control the activity of excitable cells and neuronal circuits. Using genetic manipulation, optogenetics may induce the coding of photosensitive ion channels on specific neurons: this non-invasive technology combines several approaches that allow users to achieve improved optical control and higher resolution. This technology can be applied to optical systems already present in the clinical-diagnostic field, and it has also excellent effects on biological investigations and on therapeutic strategies. Recently, several biomedical applications of optogenetics have been investigated, such as applications in ophthalmology, in bone repairing, in heart failure recovery, in post-stroke recovery, in tissue engineering, and regenerative medicine (TERM). Nevertheless, the most promising and developed applications of optogenetics are related to dynamic signal coding in cell physiology and neurological diseases. In this review, we will describe the state of the art and future insights on the impact of optogenetics on regenerative medicine.

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Section: Molecular Pathways In Optogeneticsmentioning

confidence: 99%

The Impact of Optogenetics on Regenerative Medicine

Spagnuolo

Genovese²,

Lombardo

et al. 2019

Applied Sciences

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show abstract

“…77 The opening of these channels is modulated by light and the flux of ions across cell membranes creates an action potential, analogous to a neurone discharging. The attraction of optogenetics for inherited retinal diseases lies in the structured relay system that exists with the mammalian retina, and disorders affecting the outer retina lend themselves particularly well to visual restoration using this technique (figure 1).…”

Section: Retinal Neurodegenerative Diseasesmentioning

confidence: 99%

Genetic manipulation for inherited neurodegenerative diseases: myth or reality?

Yu‐Wai‐Man

2016

Br J Ophthalmol

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Rare genetic diseases affect about 7% of the general population and over 7000 distinct clinical syndromes have been described with the majority being due to single gene defects. This review will provide a critical overview of genetic strategies that are being pioneered to halt or reverse disease progression in inherited neurodegenerative diseases. This field of research covers a vast area and only the most promising treatment paradigms will be discussed with a particular focus on inherited eye diseases, which have paved the way for innovative gene therapy paradigms, and mitochondrial diseases, which are currently generating a lot of debate centred on the bioethics of germline manipulation.

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“…This is compounded with the difficulty in determining the correct levels of opsin expression, as overexpression has been demonstrated to have cytotoxic effects. The FDA has recently cleared an application for optogenetic gene therapy for the treatment of RP, which will allow clinical trials in humans to commence (Francis et al, 2013 ; RetroSense, 2015 ). The treatment aims to restore photosensitivity of photoreceptors, bypassing the need for a separate light activation source.…”

Section: Clinical Challenges For Optogenetic Augmentationmentioning

confidence: 99%

Prospects for Optogenetic Augmentation of Brain Function

Jarvis

Schultz

2015

Front. Syst. Neurosci.

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The ability to optically control neural activity opens up possibilities for the restoration of normal function following neurological disorders. The temporal precision, spatial resolution, and neuronal specificity that optogenetics offers is unequalled by other available methods, so will it be suitable for not only restoring but also extending brain function? As the first demonstrations of optically “implanted” novel memories emerge, we examine the suitability of optogenetics as a technique for extending neural function. While optogenetics is an effective tool for altering neural activity, the largest impediment for optogenetics in neural augmentation is our systems level understanding of brain function. Furthermore, a number of clinical limitations currently remain as substantial hurdles for the applications proposed. While neurotechnologies for treating brain disorders and interfacing with prosthetics have advanced rapidly in the past few years, partially addressing some of these critical problems, optogenetics is not yet suitable for use in humans. Instead we conclude that for the immediate future, optogenetics is the neurological equivalent of the 3D printer: its flexibility providing an ideal tool for testing and prototyping solutions for treating brain disorders and augmenting brain function.

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Proceedings of the First International Optogenetic Therapies for Vision Symposium

Cited by 15 publications

References 60 publications

The Impact of Optogenetics on Regenerative Medicine

The Impact of Optogenetics on Regenerative Medicine

Genetic manipulation for inherited neurodegenerative diseases: myth or reality?

Prospects for Optogenetic Augmentation of Brain Function

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