Proceedings of the North American Society of Head and Neck Pathology, Los Angeles, CA, March 20, 2022: Emerging Entities in Salivary Gland Tumor Pathology

Microsecretory adenocarcinoma of the skin, a novel type of sweat gland carcinoma: Report of three additional cases

“…In 2019, Bishop et al 5 published a series of five low‐grade salivary gland adenocarcinomas sharing the same distinct histopathological features, and carrying a gene fusion involving MEF2C (breakpoint: exon 7) and SS18 (breakpoint: exon 4) genes. This newly reported gene fusion drives the unique morphological features of this new entity described as a microsecretory adenocarcinoma (MSA) of the salivary glands and a following publication extended to 24 cases consolidated this initial observation 6,7 . Following this initial reports, six cases were published showing the primary localization of this new entity in the skin 8–10 …”

“…This newly reported gene fusion drives the unique morphological features of this new entity described as a microsecretory adenocarcinoma (MSA) of the salivary glands and a following publication extended to 24 cases consolidated this initial observation. 6,7 Following this initial reports, six cases were published showing the primary localization of this new entity in the skin. [8][9][10] We report three additional cases of cutaneous adnexal tumors that share similar morphological and genetic features and represent the cutaneous counterpart of MSA.…”