Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies

Rossi, P. Justin; Gündüz, Ayşegül; Judy, Jack W.; Wilson, Linda; Machado, André G.; Giordano, James; Elias, W. Jeff; Rossi, Marvin A.; Butson, Christopher L.; Fox, Michael; Pouratian, Nader; Swann, Nicole C.; Hemptinne, Coralie de; Gross, Robert E.; Chizeck, H.J.; Tagliati, Michele; Lozano, Andrés M.; Goodman, Wayne K.; Langevin, Jean-Philippe; Alterman, Ron L.; Akbar, Umer; Gerhardt, Greg A.; Grill, Warren M.; Hallett, Mark; Herrington, Todd M.; Herron, Jeffrey A.; Horne, Craig van; Kopell, Brian H.; Lang, Anthony E.; Lungu, Codrin; Martínez-Ramírez, Daniel; Mogilner, Alon Y.; Molina, Rene; Opri, Enrico; Otto, Kevin J.; Oweiss, Karim G.; Pathak, Yagna; Shukla, Aparna Wagle; Shute, Jonathan; Sheth, Sameer A.; Shih, Ludy C.; Steinke, G. Karl; Tröster, Alexander I.; Vanegas, Nora; Zaghloul, Kareem A.; Cendejas-Zaragoza, Leopoldo; Verhagen, Leo; Foote, Kelly D.; Okun, Michael S.

doi:10.3389/fnins.2016.00119

Cited by 34 publications

(26 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The real-time visualization of cortical activity may be useful for intraoperative monitoring. Recent studies emphasize the benefits of a closed-loop DBS system, but the best biomarker to detect changes in brain activity remains to be determined (Johnson et al, 2016; Rossi et al, 2016). However, a multi-channel NIRS system might spur the development of a new generation of DBS systems.…”

Section: Discussionmentioning

confidence: 99%

Changes in Motor-Related Cortical Activity Following Deep Brain Stimulation for Parkinson’s Disease Detected by Functional Near Infrared Spectroscopy: A Pilot Study

Morishita

Higuchi

Saita

et al. 2016

Front. Hum. Neurosci.

View full text Add to dashboard Cite

It remains unclear how deep brain stimulation (DBS) modulates the global neuronal network involving cortical activity. We aimed to evaluate changes in cortical activity in six (two men; four women) patients with Parkinson’s disease (PD) who underwent unilateral globus pallidus interna (GPI) DBS surgery using a multi-channel near infrared spectroscopy (NIRS) system. As five of the patients were right-handed, DBS was performed on the left in these five cases. The mean age was 66.8 ± 4.0 years. The unified Parkinson’s disease rating scale (UPDRS) motor scores were evaluated at baseline and 1- and 6-month follow-up. Task-related NIRS experiments applying the block design were performed at baseline and 1-month follow-up. The mean of the total UPDRS motor score was 48.5 ± 11.1 in the off-medication state preoperatively. Postoperatively, total UPDRS motor scores improved to 26.8 ± 16.6 (p < 0.05) and 22.2 ± 8.6 (p < 0.05) at 1- and 6-month follow-up, respectively. A task-related NIRS experiment showed a postoperative increase in the cortical activity of the prefrontal cortex comparable to the preoperative state. To our knowledge, this is the first study to use a multi-channel NIRS system for PD patients treated with DBS. In this pilot study, we showed changes in motor-associated cortical activities following DBS surgery. Therapeutic DBS was concluded to have promoted the underlying neuronal network remodeling.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in Motor-Related Cortical Activity Following Deep Brain Stimulation for Parkinson’s Disease Detected by Functional Near Infrared Spectroscopy: A Pilot Study

Morishita

Higuchi

Saita

et al. 2016

Front. Hum. Neurosci.

View full text Add to dashboard Cite

show abstract

“…However, perhaps the most exciting impact of reduced power demands might be the possibility of reducing rechargeable battery size sufficiently to enable skull mounted IPGs. [20][21][22] How might aDBS systems infer the current state of activity in the pathological circuits with which they interact? Essentially information can be derived from peripheral measures of motor state, such as the monitoring of tremor or involuntary writhing movements (dyskinesias), directly from recordings of brain activity, or through a combination of these approaches.…”

mentioning

confidence: 99%

“…1). An example of amplitude-responsive aDBS is DBS which is delivered according to the level of beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) Hz) local field potential (LFP) activity recorded in the subthalamic nucleus (STN); we do not know for sure whether beta activity is causally important or not, but it correlates with motor impairment in PD patients undergoing functional neurosurgery 29 and thereby provides a surrogate for whatever may be mechanistically at play.…”

mentioning

confidence: 99%

Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy

et al. 2017

View full text Add to dashboard Cite

Continuous high-frequency DBS is an established treatment for essential tremor and Parkinson’s disease. Current developments focus on trying to widen the therapeutic window of DBS. Adaptive DBS (aDBS), where stimulation is dynamically controlled by feedback from biomarkers of pathological brain circuit activity, is one such development. Relevant biomarkers may be central, such as local field potential activity, or peripheral, such as inertial tremor data. Moreover, stimulation may be directed by the amplitude or the phase (timing) of the biomarker signal. In this review, we evaluate existing aDBS studies as proof-of-principle, discuss their limitations, most of which stem from their acute nature, and propose what is needed to take aDBS into a chronic setting.

show abstract

“…3,14,15,35 In functional neurosurgery, transcranial MRgFUS (tcMRgFUS) is definitely emerging as a noninvasive, nonprosthetic, guided, and repeatable technique for treating mostly idiopathic tremor-dominant Parkinson's disease (PD), essential tremor (ET), and neuropathic pain. 1,11,36,51 ET and PD are neurological disorders with a high prevalence. The history of their pathological progression leads to drug resistance and to the decline of quality of life.…”

mentioning

confidence: 99%

Preliminary experience with a transcranial magnetic resonance–guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson’s disease

Iacopino

Gagliardo²,

Giugno

et al. 2018

Neurosurgical Focus

View full text Add to dashboard Cite

OBJECTIVETranscranial magnetic resonance–guided focused ultrasound surgery (tcMRgFUS) is one of the emerging noninvasive technologies for the treatment of neurological disorders such as essential tremor (ET), idiopathic asymmetrical tremor-dominant Parkinson’s disease (PD), and neuropathic pain. In this clinical series the authors present the preliminary results achieved with the world’s first tcMRgFUS system integrated with a 1.5-T MRI unit.METHODSThe authors describe the results of tcMRgFUS in a sample of patients with ET and with PD who underwent the procedure during the period from January 2015 to September 2017. A monolateral ventralis intermedius nucleus (VIM) thalamic ablation was performed in both ET and PD patients. In all the tcMRgFUS treatments, a 1.5-T MRI scanner was used for both planning and monitoring the procedure.RESULTSDuring the study period, a total of 26 patients underwent tcMRgFUS thalamic ablation for different movement disorders. Among these patients, 18 were diagnosed with ET and 4 were affected by PD. All patients with PD were treated using tcMRgFUS thalamic ablation and all completed the procedure. Among the 18 patients with ET, 13 successfully underwent tcMRgFUS, 4 aborted the procedure during ultrasound delivery, and 1 did not undergo the tcMRgFUS procedure after stereotactic frame placement. Two patients with ET were not included in the results because of the short follow-up duration at the time of this study. A monolateral VIM thalamic ablation in both ET and PD patients was performed. All the enrolled patients were evaluated before the treatment and 2 days after, with a clinical control of the treatment effectiveness using the graphic items of the Fahn-Tolosa-Marin tremor rating scale. A global reevaluation was performed 3 months (17/22 patients) and 6 months (11/22 patients) after the treatment; the reevaluation consisted of clinical questionnaires, neurological tests, and video recordings of the tests. All the ET and PD treated patients who completed the procedure showed an immediate amelioration of tremor severity, with no intra- or posttreatment severe permanent side effects.CONCLUSIONSAlthough this study reports on a small number of patients with a short follow-up duration, the tcMRgFUS procedure using a 1.5-T MRI unit resulted in a safe and effective treatment option for motor symptoms in patients with ET and PD. To the best of the authors’ knowledge, this is the first clinical series in which thalamotomy was performed using tcMRgFUS integrated with a 1.5-T magnet.

show abstract

Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies

Cited by 34 publications

References 101 publications

Changes in Motor-Related Cortical Activity Following Deep Brain Stimulation for Parkinson’s Disease Detected by Functional Near Infrared Spectroscopy: A Pilot Study

Changes in Motor-Related Cortical Activity Following Deep Brain Stimulation for Parkinson’s Disease Detected by Functional Near Infrared Spectroscopy: A Pilot Study

Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy

Preliminary experience with a transcranial magnetic resonance–guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson’s disease

Contact Info

Product

Resources

About