Process analytical chemistry

Beebe, Kenneth R.; Blaser, Wayne W.; Bredeweg, Robert A.; Chauvel, Jean Paul.; Harner, Richard S.; LaPack, Mark A.; Leugers, Anne.; Martin, Daniel P.; Wright, Larry G.; Yalvac, E. Deniz.

doi:10.1021/ac00060a012

Cited by 58 publications

(17 citation statements)

References 3 publications

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“…This interest has created new opportunities for technologies such as IRE spectroscopy, which have existed in the shadows of the more common transmission and reflectance methods. Coupled with this growing interest in process analysis methods is the continued development of chemometric techniques, allowing for the analysis of data that was otherwise deemed too complex [6,7].…”

Section: Multiyariate Analysis and Infrared Emission Spectroscqpymentioning

confidence: 99%

“…Research efforts have exploited the use of NIR spectroscopy and imaging as a means for non-invasive and non-destructive evaluation [10,11]. Furthermore, the use of chemometric methods in conjunction with these spectroscopic and imaging techniques have led to heightened interest in these areas of research [6]. In a recent study remote, non-invasive NIR spectroscopy was used to identify and classify recycled plastic waste.…”

Section: Multiyariate Analysis and Infrared Emission Spectroscqpymentioning

confidence: 99%

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Chemical Non-Destructive Evaluation at the Center for Process Analytical Chemistry

Kowalski

Koch

1996

Review of Progress in Quantitative Nondestructive Evaluation

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Section: Multiyariate Analysis and Infrared Emission Spectroscqpymentioning

confidence: 99%

Section: Multiyariate Analysis and Infrared Emission Spectroscqpymentioning

confidence: 99%

Chemical Non-Destructive Evaluation at the Center for Process Analytical Chemistry

Kowalski

Koch

1996

Review of Progress in Quantitative Nondestructive Evaluation

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“…These reviews deal mainly with new technology for real time measurements and chemometric methods related to calibration modeling. Process analytical chemistry, has been reviewed in a series of six articles (2,(6)(7)(8)(9)(10), published since 1993 every two years in the journal of Analytical Chemistry; the last one (2) covers the period from March 2003 through March 2005. The authors cover analytical technologies applicable toward process, remote, real-time, and high-throughput measurements.…”

Section: Introductionmentioning

confidence: 99%

Process Analytical Technology Beyond Real-Time Analyzers: The Role of Multivariate Analysis

Kourti

2006

Critical Reviews in Analytical Chemistry

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Process analytical chemistry was recognized by Callis et al. (Analytical Chemistry, 59 (1987): 624A-635A) (1) as a field that extends well beyond real time measurements of process parameters. Process Analytical Technology is taking central stage with the 2004 guidance from the Food and Drug Administration, with a mandate much wider than real time measurements. The pharmaceutical industry is entering a new era. Chemometrics has played an integral part for the real time development of process analytical measurements (multivariate calibration) and it is ready to face the challenge of Process Analytical Technology in this wider definition.The scope of this paper is to demonstrate that multivariate, data based statistical methods, can play a critical role in process understanding, multivariate statistical process control, abnormal situation detection, fault diagnosis, process control and process scale-up, as linked to process analytical technology.

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“…Optimization and control of modern chemical processes requires high-quality chemical information [1,2]. Such information is ideally provided in real time using process analytical chemistry.…”

Section: Introductionmentioning

confidence: 99%

Design of LabVIEW®-based software for the control of sequential injection analysis instrumentation for the determination of morphine

Lenehan¹,

Barnett²,

Lewis³

2002

Journal of Automated Methods & Management in Chemistry

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LabVIEW 1 -based software for the automation of a sequential injection analysis instrument for the determination of morphine is presented. Detection was based on its chemiluminescence reaction with acidic potassium permanganate in the presence of sodium polyphosphate. The calibration function approximated linearity (range 5 £ 10 ¡10 to 5 £ 10 ¡6 M) with a line of best ¢t of yˆ1 : 05x ‡ 8 : 9164 (R 2ˆ0 : 9959), where y is the log10 signal (mV) and x is the log10 morphine concentration (M). Precision, as measured by relative standard deviation, was 0.7% for ¢ve replicate analyses of morphine standard (5 £ 10 ¡8 M). The limit of detection (3 ¼ ) was determined as 5 £ 10 ¡11 M morphine.

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Process analytical chemistry

Cited by 58 publications

References 3 publications

Chemical Non-Destructive Evaluation at the Center for Process Analytical Chemistry

Chemical Non-Destructive Evaluation at the Center for Process Analytical Chemistry

Process Analytical Technology Beyond Real-Time Analyzers: The Role of Multivariate Analysis

Design of LabVIEW®-based software for the control of sequential injection analysis instrumentation for the determination of morphine

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