Although reverse osmosis (RO) process is widely used for wastewater reclamation, it requires high amount of energy that has a major effect on the economic effectiveness of the process. Furthermore, RO membranes are susceptible to fouling, which further limits their effectiveness and increases the costs due to the need for frequent cleaning.Consequently, the use of osmotically driven membrane separation processes such as forward osmosis (FO) has gained increasing consideration, although its uptake in wastewater remediation is still low. This is because the FO process, unlike the RO process, is operated by the osmotic gradient between the feed and draw solutions; therefore, it requires minimal or no hydraulic pressure. Hence, it has unique advantages, such as possibility of low fouling, and high water recovery. Nonetheless, the long-standing problem of membrane fouling still remains a major challenge even in the performance of FO processes especially when treating raw wastewaters, which have various contaminants. Furthermore, the mechanism of fouling in FO process has been found to be different from an RO process, and there is need for further studies to elucidate the differences of FO and RO fouling. These aspects are evaluated in this review.