Process design based on physicochemical properties for the example of obtaining valuable products from plant-based extracts

Koudous, I.; Both, Simon; Gudi, Gennadi; Schulz, Hartwig; Strube, Jochen

doi:10.1016/j.crci.2013.11.003

Cited by 17 publications

(19 citation statements)

References 23 publications

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“…The scope of this article is to introduce the reader to a modern process engineering attempt for the manufacturing of traditionally used herbal extracts including physico-chemical process modelling and experimental parameter determination on lab-scale. The benefits of the modelling and simulation approach for phytoextraction are documented in detail by various studies of the authors [5,6,[14][15][16][17][18][19][20][21][22][23]. The cited articles focused mostly on the extraction of valuable compounds for plants in order to perform a further purification until a pure substance in pharma-grad is obtained, e.g., for 10-deacetylbaccatin III from yew [6,18] or artemisinin from annual mugworth [5].…”

Section: Resultsmentioning

confidence: 99%

Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)

Sixt

Strube

2018

Processes

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Traditionally used herbal medicines are deep in the consciousness of patients for the treatment of only minor diseases by self-medication. However, manufacturers of herbal medicinal products suffer from major problems such as increasing market pressure by e.g., the food supplement sector, increasing regulations, and costs of production. Moreover, due to more stringent regulation and approval processes, innovation is hardly observed, and the methods used in process development are outdated. Therefore, this study aims to provide an approach based on modern process engineering concepts and including predictive process modelling and simulation for the extraction of traditional herbal medicines as complex extracts. The commonly used solvent-based percolation is critically assessed and compared to the so-called pressurized hot water extraction (PHWE) as a new possible alternative to replace organic solvents. In the study a systematic process design for the extraction of hawthorn (Crataegus monogyna JACQ.) is shown. While for traditional percolation the solvent is optimized to a mixture of ethanol and water (70/30 v/v), the PHWE is run at a temperature of 90 • C. The extracts of various harvest batches are compared to a commercially available product based on a chromatographic fingerprint. For the first time, natural batch variability was successfully incorporated into the physico-chemical process modelling concept. An economic feasibility study reveals that the PHWE is the best choice not only from a technical point of view but also from economic aspects.

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Section: Resultsmentioning

confidence: 99%

Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)

Sixt

Strube

2018

Processes

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“…Another substance is the anti-malaria agent artemisinin from annual mugwort (Artemisia annua L.). These substances are extracted from the plant matrix and afterwards purified to pharma grade, typically by liquid-liquid extraction, chromatography, and a final crystallization [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part I: Conceptual Process Design and Cost Estimation

et al. 2018

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The article summarizes a systematic process design for the extraction and purification of artemisinin from annual mugwort (Artemisia annua L.). Artemisinin serves as an anti-malaria drug, therefore, resource-efficient and economic processes for its production are needed. The process design was based on lab-scale experiments and afterwards piloted on miniplant-scale at the institute. In this part of the article, a detailed economic feasibility studies including a reference process as a benchmark the lab-scale process and the pilot-scale process is given. Relevant differences between the different scales are discussed. The details of the respective unit operations (solid-liquid extraction, liquid-liquid extraction, chromatography and crystallization) are presented in dedicated articles. The study showed that even miniaturized lab-scale experiments are able to deliver data detailed enough for scale-up calculations on a theoretical basis. To our knowledge, a comparable systematic process design and piloting was never performed by academia before.

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“…To obtain pure substances from plant material, several process steps are necessary. A typical process may include extraction as a capture step, followed by purification steps such as liquid-liquid extraction, chromatography and crystallization [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

et al. 2018

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In this study, process integration for crystallization of a priori purified Artemisia annua L. is investigated. For this total process, the integration operation boundaries and behavior of the crystals are studied. This is performed focusing on a conceptual process design study for artemisinin, aiming towards the development of a crystallization step under given parameters by process integration. At first, different crystallization systems consisting of ethanol-water or acetone-water mixtures are compared. In subsequent steps, the metastable zone width and the behavior of the crystals regarding agglomeration and breakage are checked. Furthermore, the sensitivities of process variables based on several process parameters are investigated. Additionally, the final process integration of crystallization as a combined purification and isolation step is studied.

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Process design based on physicochemical properties for the example of obtaining valuable products from plant-based extracts

Cited by 17 publications

References 23 publications

Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)

Systematic Design and Evaluation of an Extraction Process for Traditionally Used Herbal Medicine on the Example of Hawthorn (Crataegus monogyna JACQ.)

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part I: Conceptual Process Design and Cost Estimation

Systematic and Model-Assisted Process Design for the Extraction and Purification of Artemisinin from Artemisia annua L.—Part IV: Crystallization

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