Process Design of Continuous Powder Blending Using Residence Time Distribution and Feeding Models

Gyürkés, Martin; Madarász, Lajos; Köte, Ákos; Domokos, András; Mészáros, Dániel; Beke, Aron K.; Nagy, Brigitta; Marosi, György; Pataki, Hajnalka; Nagy, Zsombor Kristóf; Farkas, Attila

doi:10.3390/pharmaceutics12111119

Cited by 20 publications

(3 citation statements)

References 37 publications

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“…Most studies on continuous powder blending so far have been focused on varying process parameters and the resulting effects on blending performance ( Gao et al, 2011 ; Järvinen et al, 2013 ; Palmer et al, 2020 ; Roth et al, 2017 ; Van Snick et al, 2017 ; Vanarase and Muzzio, 2011 ). Furthermore, theoretical modeling and simulation of continuous powder blending has been a topic of increased interest in recent years ( Galbraith et al, 2018 ; Gyürkés et al, 2020 ; Toson et al, 2018 ). The impact of powder material properties on continuous blending performance, however has not been included in most of these studies.…”

Section: Introductionmentioning

confidence: 99%

Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures

Jaspers¹,

Kulkarni²,

Tegel³

et al. 2022

International Journal of Pharmaceutics: X

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The material properties of excipients and active pharmaceutical ingredients (API's) are important parameters that affect blend uniformity of pharmaceutical powder formulations. With the current shift from batch to continuous manufacturing in the pharmaceutical industry, blending of excipients and API is converted to a continuous process. The relation between material properties and blend homogeneity, however, is generally based on batch-wise blending trials. Limited information is available on how material properties affect blending performance in a continuous process. Here, blending of API and excipients is studied in both a batch and a continuous process. Homogeneity of the resulting mixtures is analyzed, which reveals that the impact of material properties is very different in a continuous process. Where parameters such as particle size, density and flowability have significant impact on blending performance in a traditional batch process, continuous blending is more robust resulting in uniform blends for a large variety of blend compositions.

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Section: Introductionmentioning

confidence: 99%

Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures

Jaspers¹,

Kulkarni²,

Tegel³

et al. 2022

International Journal of Pharmaceutics: X

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show abstract

“…Moreover, it should be noted that not all disturbances result in a detrimental impact. It is both dependant on the magnitude and duration of such disturbances—Gyürkés et al [ 46 ] aptly discuss this concept with the use of funnel plots.…”

Section: Powder Feedingmentioning

confidence: 99%

Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance

et al. 2023

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The pharmaceutical industry is undergoing a paradigm shift towards continuous processing from batch, where continuous direct compression (CDC) is considered to offer the most straightforward implementation amongst powder processes due to the relatively low number of unit operations or handling steps. Due to the nature of continuous processing, the bulk properties of the formulation will require sufficient flowability and tabletability in order to be processed and transported effectively to and from each unit operation. Powder cohesion presents one of the greatest obstacles to the CDC process as it inhibits powder flow. As a result, there have been many studies investigating potential manners in which to overcome the effects of cohesion with, to date, little consideration of how these controls may affect downstream unit operations. The aim of this literature review is to explore and consolidate this literature, considering the impact of powder cohesion and cohesion control measures on the three-unit operations of the CDC process (feeding, mixing, and tabletting). This review will also cover the consequences of implementing such control measures whilst highlighting subject matter which could be of value for future research to better understand how to manage cohesive powders for CDC manufacture.

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“…This is done by weighting the whole dosing unit and measuring the amount of powder dispensed at every point in the process [15]. Evaluations of bulk solid dosing units, considering the given dosing rate over the process time, the so called dosing curve, are widely published in the literature [11,12,[16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. An external catch scale, on which the powder is dosed, is frequently used to avoid errors in the data by internal data preprocessing methods in the dosing units.…”

Section: Introductionmentioning

confidence: 99%

Sums of amplitudes analysis – A new non-parametric classification method for time series deviation evaluation in pharmaceutical processes

Klinken

Quodbach

2022

Powder Technology

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Process Design of Continuous Powder Blending Using Residence Time Distribution and Feeding Models

Cited by 20 publications

References 37 publications

Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures

Batch versus continuous blending of binary and ternary pharmaceutical powder mixtures

Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance

Sums of amplitudes analysis – A new non-parametric classification method for time series deviation evaluation in pharmaceutical processes

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