In this study, the effects of different carrier agents like maltodextrin, whey protein isolate, and soy protein isolate on the laboratory preparation of spray-dried bottle gourd powder were studied. The effects of addition of each carrier agent, used them both singly (5−15%) and in combination, on physical, flow, functional, morphological, and reconstitution properties were also investigated. The finished product (powder) was characterized using a laser diffraction particle size analyzer for particle analysis. The glass transition temperature was determined using a differential scanning calorimeter to understand the shelf life stability of bottle gourd powder. Bottle gourd powder showed a glass transition temperature (T g ) range of 89.63−110.39 °C and a particle size range of 95.99−102.99 μm of 50% powder particles, when all of the carrier agents under study were used in combination. Morphological analysis revealed the formation of a spherical block combining smaller blocks of powder particles produced with a combination of all three carrier agents, maltodextrin, whey protein isolate, and soy protein isolate, in a ratio of 10:10:15.